Recombinant Mouse C-reactive protein (Crp)

中文名稱：

Recombinant Mouse C-reactive protein(Crp)
貨號(hào)：

CSB-YP005991MO
規(guī)格：
來源：

Yeast
其他：

中文名稱：

Recombinant Mouse C-reactive protein(Crp)
貨號(hào)：

CSB-EP005991MO
規(guī)格：
來源：

E.coli
其他：

中文名稱：

Recombinant Mouse C-reactive protein(Crp)
貨號(hào)：

CSB-EP005991MO-B
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Mouse C-reactive protein(Crp)
貨號(hào)：

CSB-BP005991MO
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Mouse C-reactive protein(Crp)
貨號(hào)：

CSB-MP005991MO
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Crp
Uniprot No.：

P14847
別名：

Crp; Ptx1C-reactive protein
種屬：

Mus musculus (Mouse)
蛋白長度：

Full Length of Mature Protein
表達(dá)區(qū)域：

20-225
氨基酸序列

H EDMFKKAFVF PKESDTSYVS LEAESKKPLN TFTVCLHFYT ALSTVRSFSV FSYATKKNSN DILIFWNKDK QYTFGVGGAE VRFMVSEIPE APTHICASWE SATGIVEFWI DGKPKVRKSL HKGYTVGPDA SIILGQEQDS YGGDFDAKQS LVGDIGDVNM WDFVLSPEQI STVYVGGTLS PNVLNWRALN YKAQGDVFIK PQLWS
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.
基因功能參考文獻(xiàn)：
1. CRP is pathogenic in type-2 diabetes (T2DN). CRP may promote CD32b- NF-kappaB signaling to mediate renal inflammation; whereas, CRP may enhance renal fibrosis in T2DN via CD32b-Smad3-mTOR signaling. PMID: 27221338
2. FcgammaRIIb and FcgammaRIII are involved in the CRP-induced expression of MMPs and TIMP-1 and the CRP-induced phosphorylation of p38, whereas the FcgammaR-independent pathway may regulate the CRP-induced MMP-11 expression and the CRP-induced ERK1/2 phosphorylation. PMID: 28539825
3. C-reactive protein may promote acute kidney injury by impairing tubular epithelial cell regeneration via the CD32-Smad3-p27-driven inhibition of the CDK2/cyclin E complex. PMID: 27470679
4. These results suggested that CRP/oxidized low density lipoprotein/beta 2-Glycoprotein I complexes may induce lipid accumulation and inflammation in macrophages via the p38/MAPK and NFkappaB signaling pathways. PMID: 27512978
5. these data unexpectedly identify CBS as the major recognition site of mCRP and suggest that this motif may be exploited to tune the proinflammatory actions of mCRP. PMID: 26907682
6. CRP decreased adiponectin expression and multimerization, while CRP-induced decline in adiponectin might be mediated through the PI3K/Akt pathway. PMID: 26812237
7. mCRP may be responsible for promoting dementia after ischaemia and mCRP clearance could inform therapeutic avenues to reduce the risk of future dementia. PMID: 26335098
8. Effects of C-Reactive Protein on the Cardiac Differentiation of Mouse Embryonic Stem Cells PMID: 26328491
9. These data indicated that CRP may have a direct role on osteoclast and osteoblast differentiation via toll-like receptor signaling pathways. PMID: 26687448
10. Data suggest that serum amyloid P (SAP) activates CD209 DC-SIGN to regulate the innate immune system differently from C-reactive protein (CRP), and that DC-SIGN is a target for antifibrotics. PMID: 26106150
11. the acute phase protein C-reactive protein (CRP), a ligand for Fc receptors on phagocytes, enhances antibody-mediated platelet destruction by phagocytes in vivo PMID: 25548320
12. CRP has therapeutic potential against cancer through decreasing the accumulation of M2 macrophages and angiogenesis within tumors. PMID: 25088786
13. Orphan nuclear receptor Errgamma induces C-reactive protein gene expression through induction of ER-bound Bzip transmembrane transcription factor CREBH. PMID: 24466039
14. The interactions of CRP and the BBB are a two-phase process, with increased paracellular permeability at a high dose that enables its entry into the CNS and serves to induce reactive gliosis and impair CNS function. PMID: 23018453
15. In mice with photochemically induced thrombosis, acrolein produced at the locus of infarction increased the level of IL-6 and then CRP in plasma. PMID: 23763486
16. CRP directly inhibits tumoral lymphangiogenesis and lymph node metastasis in mice. PMID: 23859309
17. Which processes in glucose homeostasis are altered by CRP? Data suggest that CRP attenuates insulin-induced skeletal muscle blood flow; CRP contributes to insulin resistance via IgG receptor IIB-mediated inhibition of glucose delivery to muscle. PMID: 23069625
18. CRP is not only a biomarker, but also a mediator in DKD. PMID: 21744073
19. C-reactive protein promotes acute renal inflammation and fibrosis in unilateral ureteral obstructive nephropathy in mice. PMID: 21383672
20. These findings reveal a novel nutrient-dependent interaction between Sirt1 and HNF-1alpha which results in regulation of Crp expression. PMID: 21176092
21. Studies show that CRP itself may have a pathogenic role in the development of pressure overload-induced cardiac remodeling, possibly through enhanced inflammation and oxidative stress. PMID: 21220701
22. No reduction of atherosclerosis in C-reactive protein (CRP)-deficient mice. PMID: 21149301
23. Modified and natural C-reactive protein have opposite effects on atherosclerosis in apolipoprotein E-deficient mice. PMID: 16087790
24. the contribution of CRP's ability of activating the classical pathway of complement in the protection of mice from lethal infection with virulent Streptococcus pneumoniae type 3 PMID: 16547275
25. nCRP can facilitate cardiovascular disease through impairment of endothelium-dependent vasoreactivity, in a manner that involves increased iNOS activity and a potential for increased peroxynitrite formation. PMID: 17669410
26. the response to vascular injury provoked by human C-Reactive Protein in ovariectomized C-reactive protein transgenic mice depends on Fc gamma RI and probably requires its expression by F4/80+ cells PMID: 18063701
27. In vivo analyses revealed significant increases in TF expression and decreases in TFPI expression in carotid arteries of CRP-Tg mice versus WT mice. PMID: 18276908
28. CRP plays a crucial role in the induction, amplification, and prolongation of inflammatory processes, including atherosclerotic lesions PMID: 18402807
29. C-reactive protein has a role in impaired endothelial function PMID: 18433756
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亞細(xì)胞定位：

Secreted.
蛋白家族：

Pentraxin family
組織特異性：

Found in plasma.
數(shù)據(jù)庫鏈接：

KEGG: mmu:12944

STRING: 10090.ENSMUSP00000044665

UniGene: Mm.28767