Recombinant Kinesin-like protein unc-104 (unc-104), partial

中文名稱：

秀麗隱桿線蟲unc-104重組蛋白
貨號：

CSB-YP326425CXY
說明書：

MSDS Datasheet
規(guī)格：
來源：

Yeast
其他：

中文名稱：

秀麗隱桿線蟲unc-104重組蛋白
貨號：

CSB-EP326425CXY
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
其他：

中文名稱：

秀麗隱桿線蟲unc-104重組蛋白
貨號：

CSB-EP326425CXY-B
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

秀麗隱桿線蟲unc-104重組蛋白
貨號：

CSB-BP326425CXY
說明書：

MSDS Datasheet
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

秀麗隱桿線蟲unc-104重組蛋白
貨號：

CSB-MP326425CXY
說明書：

MSDS Datasheet
規(guī)格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

unc-104
Uniprot No.：

P23678
別名：

unc-104; C52E12.2; Kinesin-like protein unc-104; Uncoordinated protein 104
種屬：

Caenorhabditis elegans
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Motor protein involved in microtubule-associated anterograde transport. Regulates the transport of synaptic vesicle precursors in the axon of DA motor neurons. Regulates the polarized sorting of axonal proteins. Essential for the transport of synaptic components during the synaptic remodeling of the DD motor neuron, probably downstream of cdk-5 and/or pct-1/cyy-1 complex. Required for the anterograde transport of neuropeptide-containing dense core vesicles along axons. Involved in necrotic cell death.
基因功能參考文獻：
1. Synaptic vesicle bound small GTPase ARL-8 activates UNC-104 by unlocking the autoinhibition. The results demonstrate that the autoinhibitory mechanism is utilized to regulate the distribution of transport cargoes and is important for synaptogenesis in vivo. PMID: 27524618
2. LIN-2 and SYD-2 both positively affect the velocity of UNC-104 PMID: 27172328
3. findings indicate that autophagy is spatially regulated in neurons through the transport of ATG-9 by KIF1A/UNC-104 to regulate neurodevelopment PMID: 27396362
4. Reduced function of UNC-104 accelerates motor circuit dysfunction with age, whereas upregulation of UNC-104 significantly improves motor function at advanced ages and also mildly extends lifespan. In addition, UNC-104-overexpressing animals outperform wild-type controls in associative learning and memory tests. PMID: 26877087
5. This study establishes an essential role of the CC1-FHA dimer for KIF1A/unc-104-mediated neuronal transport. PMID: 23669038
6. Protein with Tau-Like repeats (PTL)-1 affects retrograde axonal transport of uncoordinated (UNC)-104 protein in Caenorhabditis elegans. PMID: 21569846
7. putative UNC-104 interactors, namely UNC-16(JIP3), DNC-1(DCTN1/Glued) and SYD-2(Liprin-alpha), inherit different functions in steering UNC-104 to specific sub-cellular locations in the neuron PMID: 21195138
8. UNC-104 may get degraded at synapses upon release of cargo. PMID: 21079789
9. Unc104 neck regulates motility by switching from a self-folded, repressed state to a dimerized conformation that can support fast processive movement. PMID: 14638858
10. kinesin UNC-104 (KIF1A) is the microtubule motor specifically responsible for anterograde axonal transport of dense core vesicles at velocities of 1.6 microm/s-2.7 microm/s PMID: 15180830
11. An analysis was made of the weak interactions of ADP-Unc104 and ADP-kinesin with microtubules and their inhibition by Map2. PMID: 17326138
12. UNC-104 forms SYD-2-dependent axonal clusters (appearing during the transition from L2 to L3 larval stages), which behave in FRAP experiments as dynamic aggregates. PMID: 19880746
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亞細胞定位：

Cytoplasm, cytoskeleton. Cell projection, axon.
蛋白家族：

TRAFAC class myosin-kinesin ATPase superfamily, Kinesin family, Unc-104 subfamily
組織特異性：

Expressed in nerve ring, amphid commissure and ventral nerve cord (at protein level).
數據庫鏈接：

KEGG: cel:CELE_C52E12.2

STRING: 6239.C52E12.2b