Recombinant Influenza A virus RNA-directed RNA polymerase catalytic subunit (PB1), partial

中文名稱：

Recombinant Influenza A virus RNA-directed RNA polymerase catalytic subunit(PB1) ,partial
貨號：

CSB-YP361052IFZ
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Influenza A virus RNA-directed RNA polymerase catalytic subunit(PB1) ,partial
貨號：

CSB-EP361052IFZ
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Influenza A virus RNA-directed RNA polymerase catalytic subunit(PB1) ,partial
貨號：

CSB-EP361052IFZ-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Influenza A virus RNA-directed RNA polymerase catalytic subunit(PB1) ,partial
貨號：

CSB-BP361052IFZ
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Influenza A virus RNA-directed RNA polymerase catalytic subunit(PB1) ,partial
貨號：

CSB-MP361052IFZ
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

PB1
Uniprot No.：

P03431
別名：

PB1; RNA-directed RNA polymerase catalytic subunit; EC 2.7.7.48; Polymerase basic protein 1; PB1; RNA-directed RNA polymerase subunit P1
種屬：

Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

RNA-dependent RNA polymerase which is responsible for replication and transcription of virus RNA segments. The transcription of viral mRNAs occurs by a unique mechanism called cap-snatching. 5' methylated caps of cellular mRNAs are cleaved after 10-13 nucleotides by PA. In turn, these short capped RNAs are used as primers by PB1 for transcription of viral mRNAs. During virus replication, PB1 initiates RNA synthesis and copy vRNA into complementary RNA (cRNA) which in turn serves as a template for the production of more vRNAs.
基因功能參考文獻：
1. PB1-T296R substitution enhanced viral replication, polymerase activity and virulence. PMID: 26453960
2. The ts-mutations in PB1, PB2, and PA genes are mostly involved in the modulation of the humoral immunity, but also have a moderate effect on the cellular adaptive immune response. PMID: 26182653
3. The deletion of "UAAA" and "UAAACU" motifs in the PB1-3'-UTR significantly increased the protein expression. PMID: 23949786
4. Inhibition of PB1 by RNA interference inhibits influenza A virus replication. PMID: 21837415
5. Study identified a novel function of PB1-F2 as an indirect regulator of the influenza virus polymerase activity via its interaction with PB1. PMID: 18182088
6. the crystal structure of a large fragment of one subunit (PA) of influenza A RNA polymerase bound to a fragment of another subunit (PB1). PMID: 18660801
7. x ray crystallography of essential PB1-PB2 subunit contact of the influenza virus RNA polymerase PMID: 19461581
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亞細胞定位：

Host nucleus. Host cytoplasm.
蛋白家族：

Influenza viruses polymerase PB1 family
數據庫鏈接：

KEGG: vg:956534