Recombinant Human respiratory syncytial virus B Phosphoprotein (P)

中文名稱：

Recombinant Human respiratory syncytial virus B Phosphoprotein(P)
貨號：

CSB-YP516628HXK
說明書：

MSDS Datasheet
規(guī)格：
來源：

Yeast
其他：

中文名稱：

Recombinant Human respiratory syncytial virus B Phosphoprotein(P)
貨號：

CSB-EP516628HXK
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
其他：

中文名稱：

Recombinant Human respiratory syncytial virus B Phosphoprotein(P)
貨號：

CSB-EP516628HXK-B
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Human respiratory syncytial virus B Phosphoprotein(P)
貨號：

CSB-BP516628HXK
說明書：

MSDS Datasheet
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Human respiratory syncytial virus B Phosphoprotein(P)
貨號：

CSB-MP516628HXK
說明書：

MSDS Datasheet
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
靶點詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

P
Uniprot No.：

O42062
別名：

P; Phosphoprotein; Protein P
種屬：

Human respiratory syncytial virus B (strain B1)
蛋白長度：

full length protein
表達區(qū)域：

1-241
氨基酸序列

MEKFAPEFHG EDANNKATKF LESIKGKFAS SKDPKKKDSI ISVNSIDIEV TKESPITSGT NIINPTSEAD STPETKANYP RKPLVSFKED LTPSDNPFSK LYKETIETFD NNEEESSYSY EEINDQTNDN ITARLDRIDE KLSEILGMLH TLVVASAGPT SARDGIRDAM VGLREEMIEK IRAEALMTND RLEAMARLRN EESEKMAKDT SDEVPLNPTS KKLSDLLEDN DSDNDLSLDD F
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

Plays critical roles in regulating RNA replication and transcription through its interactions with multiple proteins. Tethers the RNA-directed RNA polymerase L to the nucleoprotein-RNA complex. Recruits the M2-1 protein, a processivity factor that is required for efficient transcription of viral RNA. Acts as a chaperone for neo-synthesized nucleoprotein by forming an N-P complex that preserves N in a monomeric and RNA-free state and prevents the association of nascent N with host cell RNAs. Recruits the host phosphatase PP1 to inclusion bodies to regulate viral transcription. Together with the nucleoprotein, sequesters host NF-kappa-B in inclusion bodies (IBs) thereby inhibiting this host defense pathway.
基因功能參考文獻：
1. Transcription inhibition by M2-2 of the HRSV based minigenome pRSVluc, required P protein phosphorylation at serines (S) in positions 116, 117, 119. PMID: 26474524
2. Several core groups of host cellular proteins were identified that interacted with human respiratory syncytial virus L and P proteins including, in both cases, protein chaperones. PMID: 25355874
3. Phosphoprotein interacts with cellular Hsp70 and tropomysin. PMID: 23892143
4. dephosphorylation at Serine54 could facilitate P-M protein interactions that probably occur during the egress of viral particles PMID: 15784905
5. P protein phosphorylation-dephosphorylation at T108 could distinguish the role of the P protein in viral transcription and replication. PMID: 17098979
6. P protein residues L135, D139, E140 and L142 are involved in homotetramerization and the residues D136, S156, T160 and E179 appear to be essential for P protein activity on viral RNA synthesis. PMID: 18179840
7. The oligomeric state and the hydrodynamic properties of human respiratory syncytial virus (HRSV) phosphoprotein (P), and a trypsin-resistant fragment (X) that includes its oligomerization domain were analyzed. PMID: 18300250
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亞細胞定位：

Virion. Host cytoplasm.
蛋白家族：

Pneumovirus P protein family
數(shù)據(jù)庫鏈接：

KEGG: vg:1489821