Recombinant Human Transcription termination factor 2 (TTF2), partial

中文名稱：

人TTF2重組蛋白
貨號：

CSB-YP891793HU
規(guī)格：
來源：

Yeast
其他：

中文名稱：

人TTF2重組蛋白
貨號：

CSB-EP891793HU
規(guī)格：
來源：

E.coli
其他：

中文名稱：

人TTF2重組蛋白
貨號：

CSB-EP891793HU-B
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人TTF2重組蛋白
貨號：

CSB-BP891793HU
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

人TTF2重組蛋白
貨號：

CSB-MP891793HU
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

TTF2
Uniprot No.：

Q9UNY4
別名：

F2; Factor 2; Factor2; HuF 2; HuF2; Human factor 2; Lodestar homolog; Lodestar protein; RNA polymerase II termination factor; Transcription release factor 2; Transcription termination factor 2; Transcription termination factor RNA polymerase II; TTF2; TTF2_HUMAN
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

DsDNA-dependent ATPase which acts as a transcription termination factor by coupling ATP hydrolysis with removal of RNA polymerase II from the DNA template. May contribute to mitotic transcription repression. May also be involved in pre-mRNA splicing.
基因功能參考文獻：
1. hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing PMID: 12927788
2. TTF2 is the only ATP-dependent termination activity associated with Pol II transcription elongation complexes, is largely unaffected by template position, and is impervious to the phosphorylation state of the polymerase. PMID: 15125840
3. Importantly, the mitotic phenotype seen with TTF2-siRNA is rescued by expression of the siRNA-resistant GFP-tagged TTF2 proving that reduced TTF2 is responsible for the retention of RNA polymerase II on mitotic chromosomes. PMID: 15467445
亞細(xì)胞定位：

Cytoplasm. Nucleus. Note=Cytoplasmic during interphase. Relocates to the nucleus as cells enter mitosis.
蛋白家族：

SNF2/RAD54 helicase family
數(shù)據(jù)庫鏈接：

HGNC: 12398

OMIM: 604718

KEGG: hsa:8458

STRING: 9606.ENSP00000358478

UniGene: Hs.32333