Recombinant Human Thyroid hormone receptor beta (THRB)

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文獻(xiàn)引用 (2)

中文名稱：

人THRB重組蛋白
品名簡(jiǎn)稱：

Recombinant Human THRB protein
貨號(hào)：

CSB-EP023514HU
說明書：

MSDS Datasheet
規(guī)格：

￥1344
圖片：
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP023514HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) THRB.

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP023514HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) THRB.
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
引用文獻(xiàn)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

Greater than 90% as determined by SDS-PAGE.
基因名：

THRB
Uniprot No.：

P10828
別名：

Avian erythroblastic leukemia viral (v erb a) oncogene homolog 2; C ERBA 2; C ERBA BETA; c-erbA-2; c-erbA-beta; ERBA 2; ERBA BETA; ERBA2; Erythroblastic leukemia viral (v erb a) oncogene homolog 2 avian; generalized resistance to thyroid hormone; GRTH; MGC126109; MGC126110; NR1A2; Nuclear receptor subfamily 1 group A member 2; Oncogene ERBA2; PRTH; THB_HUMAN; THR1; THRB 1; THRB 2; thrB; THRB1; THRB2; Thyroid hormone nuclear receptor beta variant 1; Thyroid hormone receptor beta 1; Thyroid hormone receptor beta 2; Thyroid hormone receptor beta; Thyroid hormone receptor, beta (erythroblastic leukemia viral (v erb a) oncogene homolog 2, avian)
種屬：

Homo sapiens (Human)
蛋白長(zhǎng)度：

Full Length
來源：

E.coli
分子量：

68.8kDa
表達(dá)區(qū)域：

1-461aa
氨基酸序列

MTPNSMTENGLTAWDKPKHCPDREHDWKLVGMSEACLHRKSHSERRSTLKNEQSSPHLIQTTWTSSIFHLDHDDVNDQSVSSAQTFQTEEKKCKGYIPSYLDKDELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標(biāo)簽：

N-terminal 6xHis-SUMO-tagged
產(chǎn)品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

3-7 business days
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

引用文獻(xiàn)

Insights into spirotetramat-induced thyroid disruption during zebrafish (Danio rerio) larval development: An integrated approach with in vivo, in vitro, and in silico analyses F Jiao,Environmental pollution,2023
Disruptive effects of two organotin pesticides on the thyroid signaling pathway in Xenopus laevis during metamorphosis Shuying Li, et al,Science of The Total Environment,2019

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.
基因功能參考文獻(xiàn)：
1. These data indicate that m-TRbeta1 can act as a tumor suppressor in hepatocarcinoma and its role was significantly better than that of TRbeta1. PMID: 29679278
2. Thyroid hormone receptor beta and NCOA4 regulate terminal erythrocyte differentiation. PMID: 28864529
3. Report of a novel mutation T273R in the THRB gene of patients exhibiting signs of the syndrome of resistance to thyroid hormone. Authors propose that the trans-activating function of TRbeta is likely dominantly hindered in these patients. PMID: 28557707
4. Authors previously shown that Nuclear Receptor Corepressor 1 (NCoR) and the thyroid hormone receptor beta1 (TRbeta) inhibit tumor invasion. Here they show that these molecules repress VEGF-C and VEGF-D gene transcription in breast cancer cells, reducing lymphatic vessel density and sentinel lymph node invasion in tumor xenografts. PMID: 27806339
5. The results emphasized the importance of TRB1 in the regulation of HSV-1 replication in differentiated environment with neuronal phenotype. PMID: 26843385
6. In certain contexts, Rb loss enables TRbeta1-dependent suppression of SKP2 as a safeguard against RB1-deficient tumorigenesis. TRbeta2 counteracts TRbeta1, thus disrupting this safeguard and promoting development of RB1-deficient malignancies. PMID: 28972075
7. A relatively stable genome in retinoblastoma tumor cells is maintained by TRb1 and TRb2-mediated PTTG1 inhibition, counteracting Rb-deficiency-related genomic instability. PMID: 28242412
8. the actions of R429Q-TRbeta1 in Resistance to Thyroid Hormone (RTH)-Syndrome most likely reflect the reduced hormone affinity observed for this mutant rather than an alteration in target gene repertoire. PMID: 28257829
9. The present studies uncovered a novel mechanism by which thyroid hormone receptor beta could function as a tumor suppressor through modulation of TNF alpha-IkappaB alpha-NFkappaB pathway. PMID: 27254276
10. Novel THRB single nucleotide substitution-C to G in codon 340 in resistance to thyroid hormone syndrome. PMID: 28222413
11. TRbeta suppressed Runx2 transcriptional activities, thus confirming TRbeta regulation of Runx2 at functional thyroid hormone-response elements. Significantly, these findings indicate that a ratio of the tumor-suppressor TRbeta and tumor-promoting Runx2 may reflect tumor aggression and serve as biomarkers in biopsy tissues. The discovery of this TRbeta-Runx2 signaling supports the emerging role of TRbeta as a tumor supp... PMID: 27253998
12. results revealed that microRNA 200a inhibits erythroid differentiation by targeting PDCD4 and THRB PMID: 27734462
13. it was observed that ER stimulated gene expression by interacting with MEIS1 and FOXP3, and ER inhibited gene expression by interacting with THRB and GRHL1. PMID: 27035558
14. presents 1 pedigree of thyroid hormone resistance syndrome with heterozygous A317T mutation in THRbeta gene in the proband and his mother, which is the first reported mutation in Chinese and provides a comprehensive review of available literature PMID: 27537566
15. Molecular cloning and detection of TR beta isoform 4 in pituitary cells. PMID: 26513165
16. The expression of thyroid receptor beta is linked to fertility status. PMID: 26715425
17. p.H271D mutation associated with resistance thyroid hormone syndrome PMID: 26041374
18. diagnosis was confirmed by direct THRB sequencing that revealed 2 novel mutations: the heterozygous p.Ala317Ser in subject 1 and the heterozygous p.Arg438Pro in subject 2 PMID: 25738994
19. Down-regulation of THRbeta correlates with the reduction of all markers of differentiation and is associated with overexpression of some miRNAs supposed to play a role in thyroid tumorigenesis. PMID: 26003825
20. propose that the mutated C-terminal region of TRbeta1 could function as an "onco-domain" PMID: 25924236
21. cases suggested that certain RTHbeta mutants such as p.R316C might show very mild syndrome of inappropriate secretion of thyrotropin in spite of having apparent peripheral resistance to thyroid hormone PMID: 25502991
22. Loss of heterozygosity in THRB and its proximal microsatellite markers may play a role in tumorigenesis and development in invasive breast cancer. PMID: 26350179
23. Results showed that triple negative breast cancer patients expressed low level of THRB which was associated with poor outcome and enhanced resistance to both docetaxel and doxorubicin treatment. PMID: 25820519
24. It is demonstrated in this article that the A234T mutation in the THR-beta gene can cause the thyroid hormone resistance syndrome. PMID: 26273722
25. Its promoter methylation may be involved in the development of gastric cancer. PMID: 25302749
26. data indicated altered mineral metabolism in adults and children with resistance to thyroid hormone due to mutations in the THRB gene PMID: 25063548
27. data demonstrate that TR sumoylation is required for activation of the Wnt canonical signaling pathway during preadipocyte proliferation and enhances the PPARgamma signaling that promotes differentiation PMID: 25572392
28. down-regulated in hepatocellular carcinoma and precancerous peritumoral tissue PMID: 25156012
29. miR-424 or miR-503 mediate anti-proliferative and anti-invasive actions of thyroid hormone receptor beta PMID: 24796297
30. CpG methylation is not the major mechanism contributing to decreased THRB expression in ccRCC PMID: 24849932
31. Coordinated regulation of transcription and alternative splicing by the thyroid hormone receptor.Thyroid hormone receptor stimulates target gene transcription by binding to the thyroid hormone-response element in the presence of triiodothyronine. PMID: 25019984
32. The clinical and biochemical characteristics of our samples of Mediterranean populations with thyroid hormone resistance were similar to those previously described. Interestingly, in our populations we identified four novel mutations in the TRbeta gene PMID: 24722129
33. TRb expression in FTC cells decreased cancer cell proliferation, impeded tumor cell migration, and inhibited tumor growth in vivo through downregulation of the AKT-mTOR-p70 S6P signaling pathway and suppression of VEGF expression PMID: 23731250
34. T3 throid hormone enhanced the recruitment of the TRbeta1/Oct-1 complex on Octamer-transcription factor-1 site within cyclin D1 promoter. PMID: 24121026
35. ONL001656673 PMID: 20082849
36. A heterozygous mutation at codon 350 located in exon 9 of the THRB gene was detected in all the affected members of the family. It is important to consider thyroid hormone levels in association with TSH levels to prevent inappropriate treatmen PMID: 24217081
37. Using several human ROP enhancer/promoter-luciferase reporter constructs, the study found that thyroid hormone receptor beta 2 increased luciferase activities through the 5'-UTR and intron 3-4 region. PMID: 24058409
38. Alzheimer's disease brain tissues with elevated neuroserpin protein also showed increased expression of THRbeta1 and HuD PMID: 24036060
39. Results showthat thyroid hormone receptor beta1 (TRbeta1) mRNA expression was significantly reduced in gastric cancer specimens and the methylation of promoter of TRbeta1 gene in gastric cancer tissues was significantly higher than in adjacent normal tissues. PMID: 24434154
40. SIRT1 stimulates THRB1 activity in a manner that is independent of PGC-1alpha but requires SIRT1 deacetylase activity. PMID: 23922917
41. Adenovirus E1A 55R functions as a strong co-activator of TR-dependent transcription. PMID: 24136366
42. A combination of isoform-specific recruitment and tissue-specific expression of these newly identified coregulator candidates serves to customize TR function for different biological purposes in different cell types. PMID: 23558175
43. Data indicate that 3,5-diiodothyronine T2 activates the thyroid hormone receptor beta1 (TRbeta1). PMID: 23736295
44. we report a novel mutation in the THRb gene [c.986C>T (p.Thr329Ile)] in a woman and her daughter, who was also a carrier of the same mutation. PMID: 23195042
45. TR-beta and LXR-alpha competitively up-regulate the human Seladin-1 promoter, sharing the same response element, site A. PMID: 23416078
46. One SNP 5' of the thyroid hormone receptor-beta gene was associated with BDR in the childhood population and two adult populations (P-value=0.0012- PMID: 22212731
47. a novel inverse recruitment mechanism in which liganded TRbeta recruits corepressors to inhibit PLA2g2a expression. PMID: 23629656
48. THRB intronic SNPs can provide useful information on chemoradiotherapy-related severe myelotoxicity in patients with esophageal squamous cell carcinoma PMID: 23136537
49. We document a congenital disorder of cone function characterized by severely reduced L- and M-cone responses and increased S-cone responses caused by deleterious mutations in the THRbeta2 gene in thyroid resistant patients. PMID: 22551329
50. THRB mRNA expression in DTC was 90% lower than in normal controls, and this decrease was associated with a higher tumor/lymph node staging. PMID: 23183175
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相關(guān)疾病：

Generalized thyroid hormone resistance (GTHR); Generalized thyroid hormone resistance autosomal recessive (GTHRAR); Selective pituitary thyroid hormone resistance (PRTH)
亞細(xì)胞定位：

Nucleus.
蛋白家族：

Nuclear hormone receptor family, NR1 subfamily
數(shù)據(jù)庫(kù)鏈接：

HGNC: 11799

OMIM: 145650

KEGG: hsa:7068

STRING: 9606.ENSP00000348827

UniGene: Hs.187861