Recombinant Human Tensin-like C1 domain-containing phosphatase (TENC1), partial

中文名稱(chēng)：

人TNS2重組蛋白
貨號(hào)：

CSB-YP734016HU
規(guī)格：
來(lái)源：

Yeast
其他：

中文名稱(chēng)：

人TNS2重組蛋白
貨號(hào)：

CSB-EP734016HU
規(guī)格：
來(lái)源：

E.coli
其他：

中文名稱(chēng)：

人TNS2重組蛋白
貨號(hào)：

CSB-EP734016HU-B
規(guī)格：
來(lái)源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱(chēng)：

人TNS2重組蛋白
貨號(hào)：

CSB-BP734016HU
規(guī)格：
來(lái)源：

Baculovirus
其他：

中文名稱(chēng)：

人TNS2重組蛋白
貨號(hào)：

CSB-MP734016HU
規(guī)格：
來(lái)源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

TNS2
Uniprot No.：

Q63HR2
別名：

C1 domain containing phosphatase and tensin homolog; C1 domain-containing phosphatase and tensin homolog; C1 TEN; C1-TEN; C1TEN; DKFZp686D13244; FLJ16320; KIAA1075; TENC 1; TENC1; TENC1_HUMAN; Tensin 2; Tensin like C1 domain containing phosphatase; Tensin-2; Tensin-like C1 domain-containing phosphatase; TNS2
種屬：

Homo sapiens (Human)
蛋白長(zhǎng)度：

Partial
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Tyrosine-protein phosphatase which regulates cell motility proliferation and muscle-response to insulin. In muscles and under catabolic conditions, dephosphorylates IRS1 leading to its degradation and muscle atrophy. Negatively regulates PI3K-AKT pathway activation.
基因功能參考文獻(xiàn)：
1. Patients with low TNS2 expression showed poor relapse-free survival rates for breast and lung cancers. These results strongly suggest a role of tensin2 in suppressing cell transformation and reduction of tumorigenicity. PMID: 27203214
2. p62 expression increased but C1-Ten protein decreased during muscle differentiation, supporting a role for p62 as a physiological regulator of C1-Ten. PMID: 25101860
3. Pulldown studies in human cells using Myc-tagged Tensin2 constructs revealed that DISC1 specifically interacts with the C-terminal PTB domain of Tensin2 in a phosphorylation-independent manner. PMID: 23233134
4. Results identified tensin2 as a Syk-binding protein. PMID: 22019427
5. Here, we report complete chemical shift assignments of the SH2 domain of human tensin2 determined by triple resonance experiments. PMID: 21461930
6. Tensin2 is an important new mediator in TPO/c-Mpl pathway and has a positive affect on cellular growth, at least in part through its effect on the PI3K/Akt signaling. PMID: 21527831
7. Tensin2 SH2 domain was identified to interact with nonphosphorylated ligand (DLC-1) as well as phosphorylated ligand. PMID: 21765928
8. Tensin2, in addition to regulating cytoskeletal dynamics, influences phosphoinositide-Akt signalling through its PTPase domain. PMID: 20678486
9. Data suggest that the interaction between START-GAP1 and tensin2 occurs in a PTB domain-dependent manner. manner.ty=0 PMID: 19895840
10. Differential proteolytic cleavage of Tensin2 can liberate domains with discrete localisations and functions, which has implications for the role of Tensins in cancer cell survival and motility. PMID: 19747564
11. Interaction of Axl receptor tyrosine kinase with C1-TEN. PMID: 12470648
12. C1 domain-containing phosphatase and TENsin homologue (C1-TEN) appears to be a novel intracellular phosphatase that negatively regulates the Akt/Protein kinase B signaling cascade PMID: 15817639
13. variant 3 significantly promoted the cell growth and motility of HCC cells; clonal transfectants of variant 3 were more closely packed and resulted in a higher saturation density than in the control vector transfectants PMID: 17006924
14. Tensins may represent a novel group of metastasis suppressors in the kidney, the loss of which leads to greater tumor cell motility and consequent metastasis. PMID: 19194507
15. DLC1 interaction with tensin2 through this novel focal adhesion binding site contributes to the growth-suppressive activity of DLC1. PMID: 19440389
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亞細(xì)胞定位：

Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
組織特異性：

Detected in heart, kidney, brain, thymus, spleen, liver, placenta, lung, skeletal muscle and small intestine.
數(shù)據(jù)庫(kù)鏈接：

HGNC: 19737

OMIM: 607717

KEGG: hsa:23371

STRING: 9606.ENSP00000319756

UniGene: Hs.343334