Recombinant Human Synaptonemal complex protein SC65 (LEPREL4)

中文名稱(chēng)：

人P3H4重組蛋白
貨號(hào)：

CSB-YP842152HU
規(guī)格：
來(lái)源：

Yeast
其他：

中文名稱(chēng)：

人P3H4重組蛋白
貨號(hào)：

CSB-EP842152HU
規(guī)格：
來(lái)源：

E.coli
其他：

中文名稱(chēng)：

人P3H4重組蛋白
貨號(hào)：

CSB-EP842152HU-B
規(guī)格：
來(lái)源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱(chēng)：

人P3H4重組蛋白
貨號(hào)：

CSB-BP842152HU
規(guī)格：
來(lái)源：

Baculovirus
其他：

中文名稱(chēng)：

人P3H4重組蛋白
貨號(hào)：

CSB-MP842152HU
規(guī)格：
來(lái)源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

P3H4
Uniprot No.：

Q92791
別名：

P3H4; LEPREL4; NOL55; SC65; Endoplasmic reticulum protein SC65; Leprecan-like protein 4; Nucleolar autoantigen No55; Prolyl 3-hydroxylase family member 4; Synaptonemal complex protein SC65
種屬：

Homo sapiens (Human)
蛋白長(zhǎng)度：

full length protein
表達(dá)區(qū)域：

1-437
氨基酸序列

MARVAWGLLW LLLGSAGAQY EKYSFRGFPP EDLMPLAAAY GHALEQYEGE SWRESARYLE AALRLHRLLR DSEAFCHANC SGPAPAAKPD PDGGRADEWA CELRLFGRVL ERAACLRRCK RTLPAFQVPY PPRQLLRDFQ SRLPYQYLHY ALFKANRLEK AVAAAYTFLQ RNPKHELTAK YLNYYQGMLD VADESLTDLE AQPYEAVFLR AVKLYNSGDF RSSTEDMERA LSEYLAVFAR CLAGCEGAHE QVDFKDFYPA IADLFAESLQ CKVDCEANLT PNVGGYFVDK FVATMYHYLQ FAYYKLNDVR QAARSAASYM LFDPKDSVMQ QNLVYYRFHR ARWGLEEEDF QPREEAMLYH NQTAELRELL EFTHMYLQSD DEMELEETEP PLEPEDALSD AEFEGEGDYE EGMYADWWQE PDAKGDEAEA EPEPELA
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linking of collagen fibrils. Required for normal bone density and normal skin stability via its role in hydroxylation of lysine residues in collagen alpha chains and in collagen fibril assembly.
基因功能參考文獻(xiàn)：
1. High P3H4 expression is associated with bladder cancer. PMID: 30322400
2. SC65 protein is identified as an autoimmune target in idiopathic membranous nephropathy. PMID: 23144993
亞細(xì)胞定位：

Endoplasmic reticulum.
蛋白家族：

Leprecan family
組織特異性：

Detected in fibroblasts (at protein level). Detected in spleen, prostate, testis, ovary, colon, pancreas, kidney, placenta and heart.
數(shù)據(jù)庫(kù)鏈接：

HGNC: 16946

OMIM: 617419

KEGG: hsa:10609

UniGene: Hs.446459