Recombinant Human Sorbin and SH3 domain-containing protein 1 (SORBS1), partial

中文名稱：

人SORBS1重組蛋白
貨號：

CSB-YP883617HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人SORBS1重組蛋白
貨號：

CSB-EP883617HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人SORBS1重組蛋白
貨號：

CSB-EP883617HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人SORBS1重組蛋白
貨號：

CSB-BP883617HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人SORBS1重組蛋白
貨號：

CSB-MP883617HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

SORBS1
Uniprot No.：

Q9BX66
別名：

c-Cbl-associated protein; CAP; CBL Associated Protein; Ponsin; SH3 domain protein 5; SH3D5; SH3P12; Sorbin and SH3 Domain Containing 1; Sorbin and SH3 domain-containing protein 1; Sorbs1; SRBS1_HUMAN
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions.
基因功能參考文獻：
1. SORBS1 suppresses tumor metastasis and improves the sensitivity of breast cancer cells to antineoplastic agents. PMID: 27791200
2. association between common SORBS1 genetic variations and blood pressure, presence of hypertension, and age at onset of hypertension PMID: 26962801
3. data suggest that SORBS1 might be a gene involved in diabetic nephropathy. PMID: 25476525
4. Our NMR and ITC data indicate that the SH3a and SH3b domains of CAP simultaneously bind to a long proline-rich region of vinculin with different binding specificities PMID: 24878663
5. Sequestration of the ponsin splice variant R85FL by the polyglutamine-expanded Atx7 in cell is mediated by the specific SH3C-PRR interaction, which is implicated in the pathogenesis of spinocerebellar ataxia 7. PMID: 23892081
6. The novel ponsin isoform and its interaction with Nck1/2 provide exciting insight into the convergence of signalling pathways at the costameres, and its crucial role for skeletal muscle differentiation and re-generation. PMID: 20129698
7. preliminary results indicate the depot-specific differential expression of sorbin and SH3 domain-containing-1(SORBS1) in relation to body mass index PMID: 12690089
8. SORBS1 polymorphism does not play a major role in premature pubarche, hyperandrogenism, and/or polycystic ovary syndrome in children and adolescent girls. PMID: 12849814
9. A novel isoform was identified in a yeast two-hybrid screen for A-kinase anchoring proteins expressed in the heart. PMID: 15716063
10. Soluble intracellular domain of teneurin-1 binds to the cell membrane enriched in CAP/ponsin PMID: 15777793
11. analysis of paxillin and ponsin interaction in nascent costameres of muscle cells PMID: 17462669
12. AA genotype of SORBS1 T228A polymorphism may play a role in lacunar infarction in the Japanese population. PMID: 18394047
13. These results suggest that SORBS1 and GCK are susceptibility loci for hypertension in Japanese women and that WISP1 is such a locus in men. PMID: 19282865
14. Mutation of Tyr326 altered the function of CAP during cell spreading. PMID: 19891780
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亞細胞定位：

Cell junction, adherens junction. Cell membrane. Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Nucleus. Nucleus matrix.
組織特異性：

Detected in skeletal muscle (at protein level). Widely expressed with highest levels in heart and skeletal muscle.
數據庫鏈接：

HGNC: 14565

OMIM: 605264

KEGG: hsa:10580

STRING: 9606.ENSP00000355136

UniGene: Hs.38621