ULBP1 Recombinant Monoclonal Antibody
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中文名稱：ULBP1重組抗體
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貨號(hào)：CSB-RA446786A0HU
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規(guī)格：￥1320
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圖片：
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Western Blot
Positive WB detected in: Hela whole cell lysate, MCF-7 whole cell lysate, Raji whole cell lysate, HEK293 whole cell lysate
All lanes: ULBP1 antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 28 kDa
Observed band size: 36-50 kDa
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其他：
產(chǎn)品詳情
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產(chǎn)品描述：ULBP1重組單克隆抗體（CUSABIO貨號(hào)：CSB-RA446786A0HU）是針對(duì)ULBP1蛋白設(shè)計(jì)的高特異性科研工具，該靶點(diǎn)為自然殺傷細(xì)胞活化性受體NKG2D的關(guān)鍵配體，廣泛參與腫瘤免疫監(jiān)視及感染性疾病中的天然免疫應(yīng)答調(diào)控。本抗體經(jīng)嚴(yán)格驗(yàn)證適用于ELISA和WB等檢測(cè)方法，在Western Blot實(shí)驗(yàn)中推薦使用1:500至1:2000的稀釋范圍，可穩(wěn)定識(shí)別目標(biāo)蛋白并呈現(xiàn)清晰的特異性條帶，實(shí)驗(yàn)結(jié)果顯示其具有優(yōu)異的批間一致性和低交叉反應(yīng)特性。該產(chǎn)品適用于腫瘤微環(huán)境研究、免疫細(xì)胞活化機(jī)制解析、病毒感染相關(guān)免疫逃逸等基礎(chǔ)科研領(lǐng)域，特別在探索NK細(xì)胞功能調(diào)控、腫瘤免疫逃逸機(jī)制或免疫治療靶點(diǎn)篩選等實(shí)驗(yàn)中展現(xiàn)重要應(yīng)用價(jià)值，為體外細(xì)胞實(shí)驗(yàn)、蛋白互作研究及病理模型分析提供可靠工具。
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Uniprot No.：
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基因名：
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別名：UL16-binding protein 1 (ALCAN-beta) (NKG2D ligand 1) (N2DL-1) (NKG2DL1) (Retinoic acid early transcript 1I), ULBP1, N2DL1 RAET1I
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反應(yīng)種屬：Human
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免疫原：A synthesized peptide derived from human ULBP1
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Non-conjugated
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克隆類型：Monoclonal
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抗體亞型：Rabbit IgG
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純化方式：Affinity-chromatography
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克隆號(hào)：13C8
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA, WB
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 -
Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.
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基因功能參考文獻(xiàn)：
- we show that Simian Virus 40 (SV40)...evades NK cell attack through the down regulation of...ULBP1 PMID: 26992229
- ATF4 drives ULBP1 gene expression in cancer cell lines, while the RNA-binding protein RBM4 supports ULBP1 expression by suppressing a novel alternatively spliced isoform of ULBP1 mRNA. PMID: 26565589
- expression determines intrinsic acute myeloid leukemia susceptibility to allogeneic V[gamma]9V[delta]2 T cells PMID: 24911793
- recurrence-free survival of patients with ULBP1-negative hepatocellular carcinoma (HCC) was significantly shorter than that of patients with ULBP1-positive HCC PMID: 21756848
- recombinant ULBP1 fused to CD45 caused a reduction in cytotoxicity and degranulation by NK cells, implying a role for receptor ligand distribution in the activation of NK cell responses PMID: 21464092
- Data show that ULBP1, TFR2 and IFITM1 were associated with increased susceptibility to Vgamma9Vdelta2 T-cell cytotoxicity. PMID: 20220060
- These results identify Mult1 as a target for the MARCH family of E3 ligases PMID: 20870941
- As NKG2D ligand, ULBP1 are expressed on immature dendritic cells and plays an important role in the cytotoxic effect of NK cells against iDC. PMID: 18394338
- Data show that the protease NS3/4A of HCV down-regulates ULBP1 expression by inhibiting the transcription of ULBP1. PMID: 19500498
- ULBP1 binds to the NKG2D receptor and activates multiple signaling pathways in primary natural killer cells. PMID: 11777960
- The NKG2D ligand ULBP1 is up-regulated and readily detectable intracellularly in the endoplasmic reticulum of human cytomegalovirus-infected fibroblasts, where it colocalizes with viral protein UL16. PMID: 12847260
- ULBP1 is a human ligand of the NKG2D receptor PMID: 16901903
- The selective induction of ULBP1 expression by proteasome inhibitor drugs, along with variable NKG2D ligand expression by human tumor cells, indicates that NKG2D ligand genes are independently regulated. PMID: 19414815
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亞細(xì)胞定位：Cell membrane; Lipid-anchor, GPI-anchor. Endoplasmic reticulum.
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蛋白家族：MHC class I family
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組織特異性：Expressed in T-cells, B-cells, erythroleukemia cell lines and in a wide range of tissues including heart, brain, lung, liver, testis, lymph node, thymus, tonsil and bone marrow. Also found in fetal heart, brain, lung and liver.
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