Recombinant Human Ras-related protein Rab-18 (RAB18)

中文名稱：

人RAB18重組蛋白
貨號：

CSB-YP878835HU
規格：
來源：

Yeast
其他：

中文名稱：

人RAB18重組蛋白
貨號：

CSB-EP878835HU-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人RAB18重組蛋白
貨號：

CSB-BP878835HU
規格：
來源：

Baculovirus
其他：

中文名稱：

人RAB18重組蛋白
貨號：

CSB-MP878835HU
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

RAB18
Uniprot No.：

Q9NP72
別名：

AA959686; RAB18; RAB18 small GTPase; RAB18; member RAS oncogene family; RAB18_HUMAN; RAB18LI1; Ras related protein Rab 18; Ras-asssociated protein RAB18; Ras-related protein Rab-18; RP11-148B2.1; WARBM3
種屬：

Homo sapiens (Human)
蛋白長度：

full length protein
表達區域：

1-203
氨基酸序列

MDEDVLTTLK ILIIGESGVG KSSLLLRFTD DTFDPELAAT IGVDFKVKTI SVDGNKAKLA IWDTAGQERF RTLTPSYYRG AQGVILVYDV TRRDTFVKLD NWLNELETYC TRNDIVNMLV GNKIDKENRE VDRNEGLKFA RKHSMLFIEA SAKTCDGVQC AFEELVEKII QTPGLWESEN QNKGVKLSHR EEGQGGGACG GYC
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Required for the localization of ZFYVE1 to lipid droplets and for its function in mediating the formation of endoplasmic reticulum-lipid droplets (ER-LD) contacts. Plays a role in apical endocytosis/recycling. Plays a key role in eye and brain development and neurodegeneration.
基因功能參考文獻：
1. The authors found that the previously documented interaction between TRAPPII and COPI was also required for the recruitment of Rab18 to the lipid droplet. PMID: 28003315
2. findings suggest that RAB18 rs3765133 polymorphism affects the development of specific brain regions, particularly the cerebellum, in healthy people. PMID: 24996981
3. RAB18 is the direct target of miR-455-5p in gastric cancer. PMID: 27451075
4. Warburg Micro syndrome is caused by RAB18 deficiency. PMID: 26063829
5. These results suggest that Rab18 has an important role in viral assembly through the trafficking of the hepatitis C virus core protein to lipid droplets. PMID: 24997429
6. High RAB18 expression is associated with glioma. PMID: 24477653
7. Rab18-mediated membrane trafficking of FASN and NS3 facilitates dengue virus replication. PMID: 24696471
8. Rab18 interacts with the HCV nonstructural protein NS5A. PMID: 23935497
9. Hepatitis B virus X protein enhances proliferation of hepatoma cells through Rab18. PMID: 23471881
10. Micro syndrome has been associated with causative mutations in three disease genes: RAB3GAP1, RAB3GAP2 and RAB18. Martsolf syndrome has been associated with a mutation in RAB3GAP2. [Review] PMID: 23176487
11. performed autozygosity mapping in five consanguineous families with Warburg micro syndrome without RAB3GAP1/2 mutations and identified loss-of-function mutations in RAB18 PMID: 21473985
12. Rab18 regulates lipid droplet-associated membrane formation PMID: 15914536
13. analysis of a novel splice variant of human Rab18 gene PMID: 16147880
14. Rab18 is reduced in pituitary tumors causing acromegaly and its overexpression reverts growth hormone hypersecretion. PMID: 18349058
15. Rab18 and Rab43 have key roles in ER-Golgi trafficking. PMID: 18664496
16. Rab18 is recruited to lipid droplets during lipolysis PMID: 16207721
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相關疾病：

Warburg micro syndrome 3 (WARBM3)
亞細胞定位：

Apical cell membrane. Lipid droplet.
蛋白家族：

Small GTPase superfamily, Rab family
組織特異性：

Ubiquitous.
數據庫鏈接：

HGNC: 14244

OMIM: 602207

KEGG: hsa:22931

STRING: 9606.ENSP00000349415

UniGene: Hs.406799