Recombinant Human Protein G6b (G6B), partial

中文名稱：

人MPIG6B重組蛋白
貨號：

CSB-YP004116HU1
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人MPIG6B重組蛋白
貨號：

CSB-EP004116HU1
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人MPIG6B重組蛋白
貨號：

CSB-EP004116HU1-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人MPIG6B重組蛋白
貨號：

CSB-BP004116HU1
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人MPIG6B重組蛋白
貨號：

CSB-MP004116HU1
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

MPIG6B
Uniprot No.：

O95866
別名：

MPIG6B; C6orf25; G6B; G6B-B; Megakaryocyte and platelet inhibitory receptor G6b; Protein G6b
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Inhibitory receptor that acts as a critical regulator of hematopoietic lineage differentiation, megakaryocyte function and platelet production. Inhibits platelet aggregation and activation by agonists such as ADP and collagen-related peptide. This regulation of megakaryocate function as well as platelet production ann activation is done through the inhibition (via the 2 ITIM motifs) of the receptors CLEC1B and GP6:FcRgamma signaling. Appears to operate in a calcium-independent manner.; Isoform B, displayed in this entry, is the only isoform to contain both a transmembrane region and 2 immunoreceptor tyrosine-based inhibitor motifs (ITIMs) and, thus, the only one which probably has a role of inhibitory receptor. Isoform A may be the activating counterpart of isoform B.
基因功能參考文獻：
1. G6B seems to act through an autosomal recessive mode of disease transmission in this family and regarded as the gene responsible for the observed hematological disorder. PMID: 27743390
2. Heparin might modulate the interaction of G6b with its as yet unidentified protein ligand PMID: 15848171
3. G6B represents a novel inhibitory receptor found on the surface of platelets PMID: 17311996
4. G6b-B expression is highly restricted to peripheral CD4+ T cells and up-regulated by the IL-4-induced STAT6 pathway, suggesting that G6b-B is involved in regulation of the immune response by CD4+ T cell-mediated and IL-4 induced regulatory mechanisms. PMID: 17678728
5. G6b-B inhibits constitutive and agonist-induced signaling by glycoprotein VI and CLEC-2. PMID: 18955485
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相關疾病：

Thrombocytopenia, anemia, and myelofibrosis (THAMY)
亞細胞定位：

[Isoform E]: Endoplasmic reticulum. Golgi apparatus.; [Isoform D]: Endoplasmic reticulum. Golgi apparatus.; [Isoform B]: Cell membrane; Single-pass type I membrane protein.; [Isoform A]: Cell membrane; Single-pass type I membrane protein.
組織特異性：

Expressed in platelets. Expressed in a restricted set of hematopoietic cell lines including the erythroleukemia cell line K-562 and the T-cell leukemia cell lines MOLT-4 and Jurkat. Not detected in the monocyte-like cell line U-937, the B-cell-like cell l
數據庫鏈接：

HGNC: 13937

OMIM: 606520

KEGG: hsa:80739

STRING: 9606.ENSP00000364964

UniGene: Hs.247879