Recombinant Human Proline-rich protein 11 (PRR11)

中文名稱：

人PRR11重組蛋白
貨號：

CSB-YP836225HU
規(guī)格：
來源：

Yeast
其他：

中文名稱：

人PRR11重組蛋白
貨號：

CSB-EP836225HU-B
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人PRR11重組蛋白
貨號：

CSB-BP836225HU
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

人PRR11重組蛋白
貨號：

CSB-MP836225HU
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

PRR11
Uniprot No.：

Q96HE9
別名：

FLJ11029 ; Homo sapiens proline rich 11 ; Proline rich protein 11 ; Proline-rich protein 11; PRR 11; Prr11; PRR11_HUMAN; transcription repressor of MHCII
種屬：

Homo sapiens (Human)
蛋白長度：

full length protein
表達(dá)區(qū)域：

1-360
氨基酸序列

MPKFKQRRRK LKAKAERLFK KKEASHFQSK LITPPPPPPS PERVGISSID ISQSRSWLTS SWNFNFPNIR DAIKLWTNRV WSIYSWCQNC ITQSLEVLKD TIFPSRICHR ELYSVKQQFC ILESKLCKLQ EALKTISESS SCPSCGQTCH MSGKLTNVPA CVLITPGDSK AVLPPTLPQP ASHFPPPPPP PPLPPPPPPL APVLLRKPSL AKALQAGPLK KDGPMQITVK DLLTVKLKKT QSLDEKRKLI PSPKARNPLV TVSDLQHVTL KPNSKVLSTR VTNVLITPGK SQMDLRKLLR KVDVERSPGG TPLTNKENME TGTGLTPVMT QALRRKFQLA HPRSPTPTLP LSTSSFDEQN
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點(diǎn)詳情

功能：

Plays a critical role in cell cycle progression.
基因功能參考文獻(xiàn)：
1. PRR11 plays an oncogenic role in hepatocellular carcinoma (HCC) progression, through activating the Wnt/beta-catenin signaling pathway, and may represent a valuable prognostic marker and therapeutic target for HCC. PMID: 30248355
2. PRR11 positively regulated cell proliferation-related proteins, including c-myc and cyclin D1, and increased and decreased the expression of matrix metalloproteinase 2 and tissue inhibitor of metalloproteinase 2 and PRR11 expression was mediated by the phosphoinositide 3-kinase/AKT/beta-catenin signaling pathway. PMID: 30165366
3. these findings further illustrate the suppressive role of miR-195 in prostate cancer (PCa), and indicate a novel role of PRR11 in PCa. Importantly, the newly identified miR-195/PRR11 axis may aid with identifying potential therapeutic targets in PCa. PMID: 29393495
4. PRR11 regulated self-renewal and tumorigenicity of gastric cancer stem cells through MAPK signaling, and could be used as a therapeutic target for gastric cancer. PMID: 30007956
5. these findings indicated that miR-144-3p induced cell cycle arrest and apoptosis in pancreatic cancer by targeting PRR11. PMID: 28574724
6. p53 negatively regulates the expression of the PRR11-SKA2 bidirectional transcription unit through NF-Y, suggesting that the inability to repress the PRR11-SKA2 bidirectional transcription unit after loss of p53 might contribute to tumorigenesis. PMID: 28257042
7. Microarray analysis revealed that several genes involved in cell proliferation, cell adhesion, and cell migration were altered in PRR11-knockout cells. PMID: 25971332
8. PRR11 may be widely activated in human gastric cancer. PMID: 26252227
9. Targeted depletion of PRR11 caused a dramatic cell cycle arrest followed by massive apoptotic cell death, and eventually resulted in a significant decrease in growth and viability in lung cancer cell lines. PMID: 25973065
10. PRR11-SKA2 bidirectional transcription unit, which is a novel direct target of NF-Y, is essential for the accelerated proliferation and motility of lung cancer cells PMID: 26162986
11. Overexpression of PRR11 inhibits cell proliferation and induces premature chromatin condensation. PMID: 25666944
12. our results strongly demonstrated that this newly identified gene, PRR11, had a critical role in both cell cycle progression and tumorigenesis, and might serve as a novel potential target in the diagnosis and/or treatment of human lung cancer. PMID: 23246489
13. the apparent occurrence of an unusual TG 3' splice site in intron 10 is discussed PMID: 17672918
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亞細(xì)胞定位：

Cytoplasm. Nucleus.
組織特異性：

Ubiquitously expressed.
數(shù)據(jù)庫鏈接：

HGNC: 25619

OMIM: 615920

KEGG: hsa:55771

STRING: 9606.ENSP00000262293

UniGene: Hs.631750