Recombinant Human Polyhomeotic-like protein 3 (PHC3), partial

中文名稱：

人PHC3重組蛋白
貨號：

CSB-YP847692HU
規格：
來源：

Yeast
其他：

中文名稱：

人PHC3重組蛋白
貨號：

CSB-EP847692HU
規格：
來源：

E.coli
其他：

中文名稱：

人PHC3重組蛋白
貨號：

CSB-EP847692HU-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人PHC3重組蛋白
貨號：

CSB-BP847692HU
規格：
來源：

Baculovirus
其他：

中文名稱：

人PHC3重組蛋白
貨號：

CSB-MP847692HU
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

PHC3
Uniprot No.：

Q8NDX5
別名：

Early development regulator 3; Early development regulatory protein 3; EDR3; Homolog of polyhomeotic 3; HPH 3; hPH3; PH3; PHC 3 ; Phc3; PHC3_HUMAN; Polyhomeotic homolog 3 (Drosophila) ; Polyhomeotic homolog 3; Polyhomeotic-like protein 3
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
基因功能參考文獻：
1. Data show that polycomb-group proteins BMI1, PHC3, CBX6 and CBX7 expression was significantly increased during imatinib treatment. PMID: 26343356
2. PHC3 amplification may emerge as a biomarker in cancer. PMID: 23942079
3. SAM linker controls PHC3 SAM polymerization PMID: 22724443
4. PHC3 is a tumor suppressor in osteosarcoma cells abd its suppression may be caused by modification of polycomb repressive complex 1 in cancer cells. PMID: 20491773
5. loss of PHC3 may favor tumorigenesis by potentially disrupting the ability of cells to remain in G(0) PMID: 17001316
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亞細胞定位：

Nucleus.
數據庫鏈接：

HGNC: 15682

KEGG: hsa:80012

STRING: 9606.ENSP00000420294

UniGene: Hs.529592