1. The findings identify for the first time peroxisome-localized Miro1 variants as adapter proteins that link peroxisomes to the microtubule-dependent transport complexes including TRAK2 in the intracellular translocation of peroxisomes in mammalian cells. PMID: 29222186
2. LPS mediates intercellular tight junction destruction among TECs and RhoT1/SMAD-4/JAM-3 is a pivotal pathway to mediate the phenomenon. PMID: 29725250
3. a key role of Miro1, which promotes the mitochondrial transfer from multipotent mesenchymal stem cells, is reported. PMID: 29562677
4. Show that the C-terminal GTPase of the Parkin primary substrates Miro1 and Miro2 are necessary and sufficient for efficient ubiquitination. We present several new X-ray crystal structures of both Miro1 and Miro2 that reveal substrate recognition and ubiquitin transfer to be specific to particular protein domains and lysine residues. PMID: 27605430
5. Results provide evidence that ALS mutant SOD1 inhibits axonal transport of mitochondria by inducing PINK1/Parkin-dependent Miro1 degradation. PMID: 28973175
6. prolonged retention of Miro, and the downstream consequences that ensue, may constitute a central component of Parkinson's disease pathogenesis. PMID: 27618216
7. Full-length APC promotes assembly of the Miro-1/Milton-2 complex. PMID: 26658612
8. Miro and Cenp-F promote anterograde mitochondrial movement and proper mitochondrial distribution in daughter cells. PMID: 26259702
9. Data indicate that outer mitochondrial membrane protein Miro1 can stabilize phospho-mutant versions of PARK2 gene (encoding Parkin) on the outer mitochondrial membrane (OMM). PMID: 24671417
10. Details of a robust association of DISC1 with mitochondrial transport complexes containing TRAK1 and Miro1. PMID: 24092329
11. The Miro1-mediated mitochondrial transport in neurons and recently highlighted involvement of Miro1 proteins in mitochondrial turnover, emerging as a key process affected in neurodegeneration. PMID: 24256248
12. CXCL12-dependent cell polarization and migration are reduced in Miro-1-silenced cells PMID: 24492963
13. results indicated that the low-expression levels of RhoT1 and Smad4 were significantly associated with LNM and shorter survival. RhoT1 may be considered as a potential novel marker for predicting the outcome in patients with pancreatic cancer PMID: 22860091
14. Study shows that both PINK1 and Parkin halt mitochondrial movement; PINK1 phosphorylates Miro (1 and 2) and thereby initiates the rapid degradation of Miro through a Parkin- and proteasome-dependent pathway. PMID: 22078885
15. Moreover, we show that Miro interacts with the Kinesin-binding proteins, GRIF-1 and OIP106, suggesting that the Miro GTPases form a link between the mitochondria and the trafficking apparatus of the microtubules. PMID: 16630562
16. Miro1,2 proteins serve as a [Ca(2+)](c)-sensitive switch and bifunctional regulator for both the motility and fusion-fission dynamics of the mitochondria. PMID: 19098100
17. These data suggest that Miro1 and the kinesin adaptor Grif-1 play an important role in regulating mitochondrial transport in neurons. PMID: 19103291

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HGNC: 21168

OMIM: 613888

KEGG: hsa:55288

STRING: 9606.ENSP00000351132

UniGene: Hs.655325