Recombinant Human Methyltransferase-like protein 20 (METTL20)

中文名稱：

人ETFBKMT重組蛋白
貨號：

CSB-YP810292HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人ETFBKMT重組蛋白
貨號：

CSB-EP810292HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人ETFBKMT重組蛋白
貨號：

CSB-EP810292HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人ETFBKMT重組蛋白
貨號：

CSB-BP810292HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人ETFBKMT重組蛋白
貨號：

CSB-MP810292HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

ETFBKMT
Uniprot No.：

Q8IXQ9
別名：

ETFBKMT; C12orf72; METTL20Electron transfer flavoprotein beta subunit lysine methyltransferase; EC 2.1.1.-; ETFB lysine methyltransferase; ETFB-KMT; Protein N-lysine methyltransferase METTL20
種屬：

Homo sapiens (Human)
蛋白長度：

full length protein
表達區域：

1-262
氨基酸序列

MALSLGWKAH RNHCGLLLQA LRSSGLLLFP CGQCPWRGAG SFLDPEIKAF LEENTEVTSS GSLTPEIQLR LLTPRCKFWW ERADLWPHSD PYWAIYWPGG QALSRYLLDN PDVVRGKSVL DLGSGCGATA IAAKMSGASR ILANDIDPIA GMAITLNCEL NRLNPFPILI QNILNLEQDK WDLVVLGDMF YDEDLADSLH QWLKKCFWTY RTRVLIGDPG RPQFSGHSIQ HHLHKVVEYS LLESTRQENS GLTTSTVWGF QP
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Protein-lysine methyltransferase that selectively trimethylates the flavoprotein ETFB in mitochondria. Thereby, may negatively regulate the function of ETFB in electron transfer from Acyl-CoA dehydrogenases to the main respiratory chain.
基因功能參考文獻：
1. These results further indicate that METTL20-mediated protein methylation is not essential in humans but more likely modulates energy production during fasting or under other metabolic conditions where beta-oxidation is up-regulated. PMID: 29352221
2. Human METTL20 is a mitochondrial lysine methyltransferase that targets ETFbeta and modulates its activity. PMID: 25416781
3. Tagged METTL20 expressed in HEK293T cells specifically associates with the ETF and promotes the trimethylation of ETFbeta lysine residues 199 and 202 PMID: 25023281
4. The METTL20 protein is here suggested to be a protein methyltransferase, as it is shown to belong to a family of 10 human methyltransferases, some of which are shown to have lysine specific protein methyltransferase activity. PMID: 22948820
亞細胞定位：

Cytoplasm. Mitochondrion matrix.
蛋白家族：

Methyltransferase superfamily, ETFBKMT family
數據庫鏈接：

HGNC: 28739

OMIM: 615256

KEGG: hsa:254013

STRING: 9606.ENSP00000350353

UniGene: Hs.740628