Recombinant Human Ly6/PLAUR domain-containing protein 6 (LYPD6)

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文獻(xiàn)引用 (1)

中文名稱：

人LYPD6重組蛋白
貨號(hào)：

CSB-EP768237HU
說明書：

MSDS Datasheet
規(guī)格：

￥1344
圖片：
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
引用文獻(xiàn)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

Greater than 90% as determined by SDS-PAGE.
基因名：

LYPD6
Uniprot No.：

Q86Y78
別名：

LYPD6; UNQ3023/PRO9821Ly6/PLAUR domain-containing protein 6
種屬：

Homo sapiens (Human)
蛋白長度：

Full Length of Mature Protein
來源：

E.coli
分子量：

43.8kDa
表達(dá)區(qū)域：

23-171aa
氨基酸序列

AQSRDFTVKDIIYLHPSTTPYPGGFKCFTCEKAADNYECNRWAPDIYCPRETRYCYTQHTMEVTGNSISVTKRCVPLEECLSTGCRDSEHEGHKVCTSCCEGNICNLPLPRNETDATFATTSPINQTNGHPRCMSVIVSCLWLWLGLML
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標(biāo)簽：

N-terminal GST-tagged
產(chǎn)品提供形式：

Liquid or Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

3-7 business days
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

引用文獻(xiàn)

Functional interaction between Lypd6 and nicotinic acetylcholine receptors. Arvaniti M.et al,J Neurochem.,2016

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Acts as a modulator of nicotinic acetylcholine receptors (nAChRs) function in the brain. Inhibits nicotine-induced Ca(2+) influx through nAChRs. Acts as a positive regulator of Wnt/beta-catenin signaling.
基因功能參考文獻(xiàn)：
1. the Lynx protein Lypd6 binds to nAChRs in human brain extracts, and that recombinant Lypd6 decreases nicotine-induced ERK phosphorylation PMID: 27344019
2. Lypd6 appears to control Lrp6 activation specifically in membrane rafts, which is essential for downstream signaling. PMID: 23987510
3. The cloning and characterization of a novel human LU domain containing gene, LYPD6, isolated from human testis cDNA library, is reported. PMID: 19653121
亞細(xì)胞定位：

Secreted. Cytoplasm. Cell membrane; Lipid-anchor, GPI-anchor. Cell junction, synapse, synaptosome. Membrane raft.
組織特異性：

Ubiquitous. Highly expressed in brain and heart.
數(shù)據(jù)庫鏈接：

HGNC: 28751

OMIM: 613359

KEGG: hsa:130574

STRING: 9606.ENSP00000334463

UniGene: Hs.21929