Recombinant Human Intelectin-1 (ITLN1)

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中文名稱：

人ITLN1重組蛋白
品名簡稱：

Recombinant Human ITLN1 protein
貨號：

CSB-EP851976HU
說明書：

MSDS Datasheet
規(guī)格：

￥1536
圖片：
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
其他：

產(chǎn)品詳情
產(chǎn)品評價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

Greater than 85% as determined by SDS-PAGE.
基因名：

ITLN1
Uniprot No.：

Q8WWA0
別名：

(ITLN-1)(Endothelial lectin HL-1)(Galactofuranose-binding lectin)(Intestinal lactoferrin receptor)(Omentin)
種屬：

Homo sapiens (Human)
蛋白長度：

Full Length of Mature Protein
來源：

E.coli
分子量：

38.6 kDa
表達(dá)區(qū)域：

19-298aa
氨基酸序列

TDEANTYFKEWTCSSSPSLPRSCKEIKDECPSAFDGLYFLRTENGVIYQTFCDMTSGGGGWTLVASVHENDMRGKCTVGDRWSSQQGSKAVYPEGDGNWANYNTFGSAEAATSDDYKNPGYYDIQAKDLGIWHVPNKSPMQHWRNSSLLRYRTDTGFLQTLGHNLFGIYQKYPVKYGEGKCWTDNGPVIPVVYDFGDAQKTASYYSPYGQREFTAGFVQFRVFNNERAANALCAGMRVTGCNTEHHCIGGGGYFPEASPQQCGDFSGFDWSGYGTHVGYS
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標(biāo)簽：

N-terminal 10xHis-tagged and C-terminal Myc-tagged
產(chǎn)品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

3-7 business days
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

功能：

Lectin that specifically recognizes microbial carbohydrate chains in a calcium-dependent manner. Binds to microbial glycans that contain a terminal acyclic 1,2-diol moiety, including beta-linked D-galactofuranose (beta-Galf), D-phosphoglycerol-modified glycans, D-glycero-D-talo-oct-2-ulosonic acid (KO) and 3-deoxy-D-manno-oct-2-ulosonic acid (KDO). Binds to glycans from Gram-positive and Gram-negative bacteria, including K.pneumoniae, S.pneumoniae, Y.pestis, P.mirabilis and P.vulgaris. Does not bind human glycans. Probably plays a role in the defense system against microorganisms (Probable). May function as adipokine that has no effect on basal glucose uptake but enhances insulin-stimulated glucose uptake in adipocytes. Increases AKT phosphorylation in the absence and presence of insulin. May interact with lactoferrin/LTF and increase its uptake, and may thereby play a role in iron absorption.
基因功能參考文獻(xiàn)：
1. chemerin and leptin are elevated and omentin-1 and visfatin levels are decreased in Gestational diabetes mellitus women complicated by obesity. PMID: 29337272
2. Study shows omentin Val/Val (mutant homozygote) genotype increases predisposition to acne vulgaris by probably disrupting overall protein function of omentin. PMID: 30301508
3. The study showed for the first time serum omentin and visfatin levels to be decreased after lung transplantation in end-stage lung disease patients PMID: 29277835
4. ITLN1, PPARg AND TNFa GENE EXPRESSION IN VISCERAL ADIPOSE TISSUE. PMID: 30188100
5. Omentin may play a role in the pathophysiology of preterm births but it is not involved in the mechanism of preterm premature rupture of the membranes. PMID: 28440092
6. Loss of Omentin-1 expression is Associated with Carotid Plaque Instability among Ischemic Stroke Patients. PMID: 29225325
7. Val109Asp polymorphic marker of intelectin 1 gene is associated with abdominal obesity. PMID: 29482534
8. Reduced serum omentin-1 is associated with inflammatory mechanism and insulin resistance in the pathogenesis of diabetic nephropathy in type 2 diabetes mellitus patients. PMID: 28864059
9. The aims of this study were to evaluate and correlate circulating chemerin, apelin, vaspin, and omentin-1 levels in obese type 2 diabetic Egyptian patients with coronary artery stenosis (CAS), and to assess their usefulness as noninvasive diagnostic biomarkers. PMID: 28957639
10. six-month lifestyle weight loss intervention significantly increased serum levels in obese children PMID: 28833541
11. ITLN1 expression was significantly increased in asthmatic airways and in lesional skin of atopic dermatitis patients PMID: 28224996
12. Plasma omentin-1 level was significantly higher in patients with good coronary collateral circulation (CCC) than those with poor CCC (566.57+/-26.90 vs. 492.38+/-19.70 ng/mL, p=0.024). Besides, omentin-1 was positively correlated with total cholesterol, high-density lipoprotein, and gensini score but inversely with hyperlipidemia and body mass index (all p values0.05). PMID: 28123148
13. In conclusion, our study, which focused on hepatic FGF21 and omentin-1 mRNA expression, confirmed marked expression of both molecules in the liver of morbidly obese patients with NAFLD. PMID: 28820393
14. Myocardial injury leads to a decrease in ITLN1 expression in the heart and a corresponding increase in plasma levels PMID: 28687077
15. the effects of omentin-1 on KLF2 expression are mediated by p53. PMID: 29408455
16. Omentin levels are increased in cirrhotic patients without portal vein thrombosis, but do not influence platelet activity. PMID: 28465646
17. Omentin-1 levels are closely associated with the endogenous insulin reserve and may be used in follow-up of patients. PMID: 28073124
18. Omentin expression increases in the epicardial adipose tissueof non-obese coronary artery disease patients, despite a decrease in plasma levels, suggesting that omentin may play a role in the pathogenesis of coronary artery disease PMID: 27450783
19. Omentin-1 concentrations may be related to increased stroke risk PMID: 27298015
20. A decreased level of circulating omentin negatively correlated with white blood cells and procalcitonin in patients with acute respiratory distress syndrome. PMID: 27607575
21. Serum levels of omentin-1 were positively associated with increases in glycemia and incident type 2 diabetes in an older population. PMID: 28679518
22. These findings suggested that elevated serum omentin levels were only very mildly related to the changes in cardiac volume and function in chronic heart failure patients PMID: 27270246
23. Data suggest that circulating omentin-1 levels are lower in patients with PCOS (polycystic ovary syndrome) as compared to control subjects; circulating omentin-1 levels appear to correlate with insulin resistance but do not appear to correlate with overweight/obesity in these patients. [META-ANALYSIS] PMID: 27908216
24. In conclusion, DAB2 and Intelectin-1 are newly identified positive markers of mesothelioma and have potential to be included in future immunohistochemical marker panels for differentiation of epithelioid mesothelioma from pulmonary adenocarcinoma PMID: 28394802
25. This study showed that consumption of olive oil-rich diet tended to increase omentin and adiponectin in comparison with the usual diet. PMID: 27931137
26. Omentin concentrations were inversely associated with MMP-3 levels in rheumatoid arthritis patients. This relationship was influenced by population origin, rheumatoid arthritis activity and erythrocyte sedimentation rate. PMID: 27476070
27. High omentin expression is associated with Colorectal Cancer. PMID: 27216184
28. Our results indicate that the Asp allele of Val109Asp (T allele of rs2274907) is more frequent among men with coronary artery disease than healthy men, so it is possibly a risk factor for coronary artery disease in men only. PMID: 28325076
29. In type 2 diabetes mellitus, both chemerin and omentin enhance the body sensitivity to insulin, which results in increased glucose uptake and increased expression of the omentin gene was reported in nasal polyps and mesothelioma. PMID: 27516571
30. High omentin expression is associated with osteoporosis. PMID: 27614458
31. There was no difference in serum chemerin, vaspin and omentin-1 between polycystic ovary syndrome patients and healthy controls. PMID: 27225862
32. Atorvastatin increased serum omentin-1 concentrations in patients with coronary artery disease in a dose-dependent manner. PMID: 27749321
33. Omentin-1 might exert a negative effect on bone remodelling in girls with anorexia nervosa by inhibiting both bone formation and resorption. The OPG/sRANKL system plays an important role in the latter. PMID: 26662650
34. Low serum Omentin-1 level is Associated with Dilated Cardiomyopathy. PMID: 27313334
35. omentin, as compared to vaspin, seems to provide a better predictor of insulin resistance in obese individuals. PMID: 27449535
36. Data suggest that nonlinear resistance training or aerobic interval training for 12 weeks produces no significant changes in serum levels of omentin-1 and interleukin-18 in obese men; however, during a 4-week detraining period, omentin-1 decreases significantly and IL-18 increases significantly. PMID: 27636349
37. Omentin-1 expression in patients with coronary artery disease was lower in epicardial adipose tissue adjacent to coronary stenotic segments than non-stenotic segments PMID: 27352781
38. omentin reduces the development of atherosclerosis by reducing inflammatory response of macrophages through the Akt-dependent mechanisms PMID: 26714927
39. Omentin-1 levels were markedly reduced in coronary endothelium and epicardial fat but increased in plasma and atheromatous plaques (macrophages/SMCs) in coronary artery disease (CAD) patients compared with non-CAD patients PMID: 26790473
40. The mean serum omentin-1 concentration in adolescent girls with anorexia nervosa was higher than that of controls and obese girls. PMID: 25804090
41. Omentin levels were lower in both obese and non-obese PCOS patients compared to healthy controls. PMID: 26291814
42. Data show that the circulating omentin-1 levels were dramatically decreased in renal cell carcinoma (RCC) patients. PMID: 26539805
43. Although no significant difference was detected regarding omentin Val109Asp polymorphism, Val/Val genotype frequency was found to be more in patient group than control group. It may be speculated that Val/Val genotype increases the tendency for CAD. PMID: 24370683
44. Plasma omentin-1 concentrations were decreased in non-obese polycystic ovary syndrome individuals PMID: 26514948
45. Data suggest serum omentin/ITLN1 levels are down-regulated in elderly population (ages 61-82 years) with type 2 diabetes and polyneuropathy, independently of established risk factors of polyneuropathy; ITLN1 is positively correlated with adiponectin. PMID: 26094489
46. Serum omentin was associated with cardiac autonomic neuropathy in type 2 diabetes patients. PMID: 26466574
47. analysis of expression of maternal omentin-1 in humans and in the rat animal model PMID: 26144294
48. Lower levels of serum omentin in patients with pseudoexfoliation syndrome compared with healthy subjects may support the theory of systemic nature of the disease. PMID: 25264991
49. A decrease in omentin-1 levels could be an independent mortality risk factor in patient with diabetes on hemodialysis. PMID: 26293449
50. This study clearly indicates that acute aerobic exercise elicits a pro-inflammatory response (e.g. CHI3L1) with a lower anti-inflammatory effect (e.g. ITLN-1) in obese individuals. PMID: 26316585
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亞細(xì)胞定位：

Cell membrane; Lipid-anchor, GPI-anchor. Secreted.
組織特異性：

Highly expressed in omental adipose tissue where it is found in stromal vascular cells but not in fat cells but is barely detectable in subcutaneous adipose tissue (at protein level). Highly expressed in the small intestine. Also found in the heart, testi
數(shù)據(jù)庫鏈接：

HGNC: 18259

OMIM: 609873

KEGG: hsa:55600

STRING: 9606.ENSP00000323587

UniGene: Hs.50813