Recombinant Human Integrin beta-5 (ITGB5), partial

中文名稱：

人ITGB5重組蛋白
貨號：

CSB-YP011889HU1
說明書：

MSDS Datasheet
規(guī)格：
來源：

Yeast
其他：

中文名稱：

人ITGB5重組蛋白
貨號：

CSB-EP011889HU1
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
其他：

中文名稱：

人ITGB5重組蛋白
貨號：

CSB-EP011889HU1-B
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人ITGB5重組蛋白
貨號：

CSB-BP011889HU1
說明書：

MSDS Datasheet
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

人ITGB5重組蛋白
貨號：

CSB-MP011889HU1
說明書：

MSDS Datasheet
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

ITGB5
Uniprot No.：

P18084
別名：

ITGB5; Integrin beta-5
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

功能：

Integrin alpha-V/beta-5 (ITGAV:ITGB5) is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand.; (Microbial infection) Integrin ITGAV:ITGB5 acts as a receptor for adenovirus type C.
基因功能參考文獻(xiàn)：
1. High ITGB5 expression is associated with cervical cancer. PMID: 26758421
2. FAK activity regulates beta5 integrin expression and anchorage-independent cell growth in ovarian carcinoma. PMID: 24899686
3. FRMD5 regulates tumor cell motility via a dual pathway involving FRMD5 binding to integrin beta5 tail and to ROCK1 PMID: 25448675
4. Immunohistochemical analysis for alphavbeta3, alphavbeta5 and alphavbeta6 integrin subunits was performed and correlated with Ki67 and hypoxia-inducible factor (HIF)-1alpha indexes PMID: 25150423
5. Myo7a interacts with integrin beta5 and selectively promotes integrin alphavbeta5-mediated cell migration PMID: 24997346
6. we demonstrated via antibody blocking experiments that aV b5 and a6 significantly promoted hESC attachment in 2%oxygen only, whereas blockage of CD44 inhibited cell attachment in 21% O2 alone PMID: 24455718
7. Brain metastases ITGB5 expression exhibits considerable heterogeneity according to tumor origin. PMID: 24294359
8. Integrin-beta5 and zyxin mediate formation of ventral stress fibers in response to transforming growth factor beta. PMID: 24036928
9. molecular model of integrin b5 structure was prepared and stereo chemical model quality was checked. Integrin b5 active sites were identified based on insilico analysis tools. PMID: 23962022
10. BDNF enhances the migration of chondrosarcoma by increasing beta5 integrin expression through a signal transduction pathway that involves the TrkB receptor, PI3K, Akt, and NF-kappaB. PMID: 23874483
11. The top primary GWAS association of Airway hyperresponsiveness was in rs848788(P-value 7.2E-07) located within the ITGB5 genes. PMID: 23984888
12. Depletion of integrin beta5 in triple-negative breast carcinoma cells markedly reduced tumor take, growth and tumor angiogenesis, whereas reexpression of integrin beta5 rescued this phenotype; findings show a critical role for integrin beta5 in the tumorigenic potential of breast carcinoma cells PMID: 22824793
13. High beta5-integrin protein expression is associated with aggressive behavior in gastric cancer. PMID: 22561002
14. Letter: loss of integrin beta5 in polyomavirus positive Merkel cell carcinoma may influence cell adhesion/migration. PMID: 22503669
15. Cysteine-rich protein Cyr61 activates interleukin (IL)-6 production via the alphavbeta5/Akt/NF-kappaB signaling pathway in rheumatoid arthritis. PMID: 22547695
16. The beta5-integrin adhesions contribute to the TGFbeta-induced EMT and the tumorigenic potential of carcinoma cells. PMID: 20404485
17. p21-activated kinase 4 phosphorylation of integrin beta5 Ser-759 and Ser-762 regulates cell migration PMID: 20507994
18. Src kinase-mediated activation of STAT3 and subsequent angiogenic gene expression mediate the effects of integrin alpha v beta 5 and may be exploited to enhance the paracrine activities of circulating angiogenic cells. PMID: 20431064
19. Overexpression of the beta5 integrin in hematopoietic cells was associated with the inhibition of cell proliferation and apoptosis. PMID: 11877043
20. different beta5 integrins: repeated-FNK (FNKFNK764-769) and single-FNK (FNK764-766) amino acid sequences in the cytoplasmic domain. PMID: 15979906
21. Our studies suggest that the phagocytic function of beta5 integrin is regulated by an unconventional NPxY-talin-independent activation signal and argue for the existence of molecular switches in the beta5 cytoplasmic tail for adhesion and phagocytosis. PMID: 17963729
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亞細(xì)胞定位：

Membrane; Single-pass type I membrane protein.
蛋白家族：

Integrin beta chain family
數(shù)據(jù)庫鏈接：

HGNC: 6160

OMIM: 147561

KEGG: hsa:3693

STRING: 9606.ENSP00000296181

UniGene: Hs.13155