Recombinant Human Inositol 1,4,5-trisphosphate receptor type 2 (ITPR2), partial

中文名稱：

人ITPR2重組蛋白
貨號：

CSB-YP623923HU
規格：
來源：

Yeast
其他：

中文名稱：

人ITPR2重組蛋白
貨號：

CSB-EP623923HU
規格：
來源：

E.coli
其他：

中文名稱：

人ITPR2重組蛋白
貨號：

CSB-EP623923HU-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人ITPR2重組蛋白
貨號：

CSB-BP623923HU
規格：
來源：

Baculovirus
其他：

中文名稱：

人ITPR2重組蛋白
貨號：

CSB-MP623923HU
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

ITPR2
Uniprot No.：

Q14571
別名：

4; 5-trisphosphate receptor; Inositol 1 4 5 trisphosphate receptor type 2; Inositol 1,4,5-trisphosphate receptor type 2; Inositol 145 trisphosphate receptor type 2; InsP3 R2; InsP3R2; IP3 R2; IP3 receptor; IP3 receptor isoform 2; IP3R 2; IP3R2; ITPR 2; Itpr2; ITPR2_HUMAN; Type 2 inositol 1 4 5 trisphosphate receptor; Type 2 inositol 1; Type 2 inositol 145 trisphosphate receptor; Type 2 InsP3 receptor
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA.
基因功能參考文獻：
1. we systematically evaluating RCC risk-associated SNPs indentified from previous GWAS in a Chinese population, finding that one SNP located in PDZD2 and two SNPs located in ITPR2 were ccRCC-risk associated in Chinese population. PMID: 26918600
2. Data suggest miR-1290 as the new oncomiR involved in laryngeal squamous cell carcinoma pathogenesis probably through downregulation of its target genes MAF and ITPR2. PMID: 26694163
3. results show a functional role of calcium release by the ITPR2 channel and its subsequent accumulation in the mitochondria PMID: 24797322
4. High expression of inositol 1,4,5-trisphosphate receptor, type 2 is associated with acute myeloid leukemia. PMID: 25779662
5. Disrupting IP3R/Bcl-2 interaction therefore leads in those cells to increased Ca(2) release and apoptosis. Intriguingly, IP3R2 is not only implicated in apoptosis but also in the induction of senescence, another tumour-suppressive mechanism. PMID: 25499268
6. A genome-wide association study identifies ITPR2 as a susceptibility gene for Kashin-Beck disease in Han Chinese. PMID: 25303641
7. Loss of InsP3R2-mediated calcium release causes isolated anhidrosis in humans. PMID: 25329695
8. ITPR2 and hypertrophy specific gene expression is regulated, in part, by a positive feedback regulation between InsP3R2 and calcineurin-NFATc signaling pathways. PMID: 24415751
9. These data suggest that ER Ca(2+) released by IP(3) receptors may be detrimental in amyotrophic lateral sclerosis and that motor neurons are vulnerable to impaired Ca(2+) metabolism. PMID: 23131553
10. Functional IP3R2s are expressed in the mouse sinoatrial node and could serve as an additional divalent calcium ion-dependent mechanism in modulating cardiac pacemaker. PMID: 21852551
11. ITPR2 is a functional target gene of the BACH1 transcription factor according to ChIP-seq and knockdown analysis in HEK 293 cells. PMID: 21555518
12. The result of this study suggested that ITPR2 that do not modulate the risk for SALS in the German population. PMID: 19464757
13. The knock down of IP3R-2 significantly reduced the intracellular Ca2+ response and this reduced Ca2+ response did not affect the activation of CREB but significantly decreased the activation of NFAT. PMID: 21063100
14. Dystrophic (RCDMD) human muscle cells show 5-fold overexpression of IP(3)R2 and down-regulation of IP(3)R3 compared with normal human muscle cells. PMID: 20395455
15. Antibodies are detected most frequently in rheumatoid arthritis. PMID: 17437169
16. Genetic variation is susceptibility factor for amyotrophic lateral sclerosis(ALS). Involved in glutamate-mediated neurotransmission, is one of main regulators of intracellular calcium concentrations, and has important role in apoptosis. PMID: 17827064
17. Provide evidence for a functional role of the de novo coupling between hTRPC1 and IP3RII in the activation of store operated calcium entry in platelets. PMID: 18249094
18. Parathyroid hormone communicates with IP(3)R via "cAMP junctions" that allow local delivery of a supramaximal concentration of cAMP to IP(3)R, directly increasing their sensitivity to IP(3). PMID: 18936250
19. Elevated InsP(3)R2 expression was also detected in hearts from human patients with heart failure after ischemic dilated cardiomyopathy, as well as in aortic-banded hypertrophic mouse hearts. PMID: 19549843
20. Clinical trial and genome-wide association study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 18519826
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相關疾病：

Anhidrosis, isolated, with normal sweat glands (ANHD)
亞細胞定位：

Endoplasmic reticulum membrane; Multi-pass membrane protein.
蛋白家族：

InsP3 receptor family
組織特異性：

Isoform Short is found in skeletal muscle and heart.
數據庫鏈接：

HGNC: 6181

OMIM: 106190

KEGG: hsa:3709

STRING: 9606.ENSP00000370744

UniGene: Hs.512235