Recombinant Human Homeobox protein Hox-C13 (HOXC13)

中文名稱：

人HOXC13重組蛋白
貨號：

CSB-YP010674HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人HOXC13重組蛋白
貨號：

CSB-EP010674HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人HOXC13重組蛋白
貨號：

CSB-EP010674HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人HOXC13重組蛋白
貨號：

CSB-BP010674HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人HOXC13重組蛋白
貨號：

CSB-MP010674HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

HOXC13
Uniprot No.：

P31276
別名：

ECTD9; Homeo box 3G; Homeo box C13; homeobox C13; Homeobox protein Hox 3G; Homeobox protein Hox-3G; Homeobox protein Hox-C13; Homeobox protein Hox-C13a; Hox-3G; HOX3; HOX3G ; Hoxc13; HXC13; HXC13_HUMAN; NUP98; NUP98/HOXC13
種屬：

Homo sapiens (Human)
蛋白長度：

Full length protein
表達區域：

1-330
氨基酸序列

MTTSLLLHPR WPESLMYVYE DSAAESGIGG GGGGGGGGTG GAGGGCSGAS PGKAPSMDGL GSSCPASHCR DLLPHPVLGR PPAPLGAPQG AVYTDIPAPE AARQCAPPPA PPTSSSATLG YGYPFGGSYY GCRLSHNVNL QQKPCAYHPG DKYPEPSGAL PGDDLSSRAK EFAFYPSFAS SYQAMPGYLD VSVVPGISGH PEPRHDALIP VEGYQHWALS NGWDSQVYCS KEQSQSAHLW KSPFPDVVPL QPEVSSYRRG RKKRVPYTKV QLKELEKEYA ASKFITKEKR RRISATTNLS ERQVTIWFQN RRVKEKKVVS KSKAPHLHST
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Transcription factor which plays a role in hair follicle differentiation. Regulates FOXQ1 expression and that of other hair-specific genes.
基因功能參考文獻：
1. we report a novel nonsense variant (c.265C>T, p.Gln89*) in the HOXC13 gene, which resulted in a premature termination codon and is predicted either to produce a truncated protein without an essential DNA binding homeodomain or more likely to undergo nonsense-mediated RNA decay- ultimately producing the PHNED (pure hair and nail ectodermal dysplasia) phenotype. PMID: 28543635
2. Study showed that HOXC13 expression was significantly elevated in esophageal squamous cell carcinoma (ESCC), and correlated with worse clinical characteristics and poorer prognosis. HOXC13 promoted proliferation and inhibited apoptosis through repressing transcription of CASP3. PMID: 29168599
3. Mutations in Hoxc13 is associated with ectodermal dysplasia-9. PMID: 28011715
4. A novel missense mutation (c.929A > C) in HOXC13 gene associated with pure hair and nail ectodermal dysplasia (ECTD9) in a Pakistani family. PMID: 28403827
5. The microdeletions share a minimal non-coding region overlap upstream of HOXC13, with variable phenotypes depending upon HOXC13, HOXC12 or thIdentification of 5' HOXC microdeletions highlights the importance of transcriptional regulators in the aetiology of severe lower limb malformations and will improve their diagnosis and managemente HOTAIR lncRNA inclusion. PMID: 26729820
6. In conclusion, our data show a deregulation of the HOXC13 marker in welldifferentiated and dedifferentiated LPSs, possibly related to 12q13-15 chromosomal amplification. PMID: 24085196
7. Results show that duplication and nonsense mutation lead to loss of function in this gene and the role it plays in hair and nail development PMID: 23461661
8. Identification of a homozygous mutation in the HOXC13 gene in a Syrian family with autosomal-recessive pure hair and nail ectodermal dysplasia. PMID: 23315978
9. results show the strong and progressive HOX C13 overexpression in metastatic melanoma tissues and cytological samples compared to nevi and primary melanoma tissues and cells. PMID: 22583695
10. loss-of-function mutations in HOXC13 cause autosomal-recessive PHNED and further highlight the importance of HOXC13 in hair and nail development. PMID: 23063621
11. Krtap16 is a hair keratin-associated protein gene complex regulated by Hoxc13 PMID: 15385554
12. HOXC13 was highly expressed in ameloblastoma. Heterogeneous expression could improve the epithelial proliferation, and its loss may lead to the cornification and degeneration of epithelial cells. PMID: 17331444
13. Results show that HOXC13 is a member of human replicative complexes. PMID: 19182517
14. To our knowledge, this is the first case of t(11;12)(p15;q13) in de novo AML-M4 in association with FLT3 ITD mutation. Coexistence of NUP98-HOXC13 fusion and FLT3 ITD mutation is likely relevant in the process of leukemogenesis PMID: 19665070
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相關疾?。?/div>
Ectodermal dysplasia 9, hair/nail type (ECTD9)
亞細胞定位：

Nucleus.
蛋白家族：

Abd-B homeobox family
數據庫鏈接：

HGNC: 5125

OMIM: 142976

KEGG: hsa:3229

STRING: 9606.ENSP00000243056

UniGene: Hs.118608