Recombinant Human Growth arrest-specific protein 1 (GAS1)
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中文名稱：人GAS1重組蛋白
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貨號：CSB-EP009264HU-B
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說明書：
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規(guī)格：
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來源：E.coli
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共軛：Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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其他：
產(chǎn)品詳情
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純度：>85% (SDS-PAGE)
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基因名：
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Uniprot No.：
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別名：GAS-1; Gas1; GAS1_HUMAN; Growth arrest-specific protein 1; Growth-arrest-specific protein 1 precursor
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種屬：Homo sapiens (Human)
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蛋白長度：Full Length of Mature Protein
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表達(dá)區(qū)域：40-318
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氨基酸序列L AHGRRLICWQ ALLQCQGEPE CSYAYNQYAE ACAPVLAQHG GGDAPGAAAA AFPASAASFS SRWRCPSHCI SALIQLNHTR RGPALEDCDC AQDENCKSTK RAIEPCLPRT SGGGAGGPGA GGVMGCTEAR RRCDRDSRCN LALSRYLTYC GKVFNGLRCT DECRTVIEDM LAMPKAALLN DCVCDGLERP ICESVKENMA RLCFGAELGN GPGSSGSDGG LDDYYDEDYD DEQRTGGAGG EQPLDDDDGV PHPPRPGSGA AASGGRGDLP YGPGRRSS
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蛋白標(biāo)簽：Tag?type?will?be?determined?during?the?manufacturing?process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially. -
產(chǎn)品提供形式：Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand. -
復(fù)溶：We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
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儲存條件：Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
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保質(zhì)期：The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. -
貨期：Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
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注意事項：Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Datasheet ：Please contact us to get it.
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情
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功能：Specific growth arrest protein involved in growth suppression. Blocks entry to S phase. Prevents cycling of normal and transformed cells.
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基因功能參考文獻：
- Studies establish Gas1 as a negative regulator in colorectal cancer. PMID: 27401611
- These results demonstrated that miR-184 and the GAS1/Akt pathway may be a potential therapeutic target for intervertebral disc degeneration. PMID: 26805687
- WT1 modulates Akt/JNK signaling pathway mediated autophagy by controlling the expression of growth arrest-specific 1 (Gas1). PMID: 27453337
- Downregulation of GAS1 is associated with clear cell renal cell carcinoma. PMID: 28184927
- the synergistic effect of Gas1 inhibition and GDNF against glutamate-induced cell injury in human SH-SY5Y neuroblastoma cells, is reported. PMID: 26215053
- solutions structure and biophysical characterization of the multifaceted signalling effector protein growth arrest specific-1 PMID: 25888394
- This review summarizes the structure of Gas1 and molecular mechanism of action during embryonic development and cellular functions. PMID: 25429664
- GAS1 is a novel endogenous inhibitor of glomerular mesangial cell proliferation. PMID: 23254899
- Growth arrest-specific gene 1 is downregulated and inhibits tumor growth in gastric cancer. PMID: 22846196
- GAS1 induced the activity of caspase-3 and resulting in apoptosis of the cells. PMID: 22311470
- Interference of endoplasmic reticulum to Golgi transport increased immature amyloid beta protein precursor accumulation upon Gas1 expression in lipid raft fractions. PMID: 21971401
- we demonstrate that sequence variants in GAS1 can impair its physical interaction with SHH, suggesting a decrease in the SHH downstream signaling cascade as a pathogenic mechanism of disease. PMID: 21842183
- Gas1 is a novel APP-interacting protein involved in the control of APP maturation and processing. PMID: 21357679
- Growth arrest-specific gene 1 contributes to predicting metastasis or recurrence in stage II and III colorectal cancer. PMID: 21111449
- GAS1 could be considered a candidate locus for one of the types of human holoprosencephaly. PMID: 20583177
- Gas1 is related to the GDNF alpha receptors and regulates Ret signaling PMID: 16551639
- This review considers the possible involvement of GAS1 in genetic diseases, stem cell renewal, and cancer growth through its cooperative activity with Hedgehog (HH) growth factor and the HH receptor. PMID: 17726382
- Gas1 is a molecule involved in cell arrest that can induce apoptosis when over-expressed in different cell lines. PMID: 18394855
- Gas1 has all the expected properties of a melanoma tumor suppressor: suppression of metastasis in a spontaneous metastasis assay, promotion of apoptosis following dissemination of cells to secondary sites, and down-regulation in human melanoma metastasis. PMID: 18981472
- Results present evidence demonstrating that Gas1 exerts its effects inhibiting cell growth and inducing apoptosis of glioma cells in the absence of Shh. PMID: 19460624
- Results suggest that GAS1 might be a target to overcome multidrug resistance and provide a novel approach to identifying candidate genes that suppress chemoresistance of gastric cancers. PMID: 19638344
- GAS1 is preferentially expressed by human bulge cells, compared to differentiated hair follicle keratinocytes PMID: 20050020
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亞細(xì)胞定位：Cell membrane; Lipid-anchor, GPI-anchor.
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