Recombinant Human Forkhead box protein H1 (FOXH1)

中文名稱：

人FOXH1重組蛋白
貨號：

CSB-YP008817HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人FOXH1重組蛋白
貨號：

CSB-EP008817HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人FOXH1重組蛋白
貨號：

CSB-EP008817HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人FOXH1重組蛋白
貨號：

CSB-BP008817HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人FOXH1重組蛋白
貨號：

CSB-MP008817HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

FOXH1
Uniprot No.：

O75593
別名：

FAST 1; Fast 2; Fast-1; Fast-2; FAST1; Fast2; Forkhead activin signal transducer 1; Forkhead activin signal transducer 2; Forkhead box H1; Forkhead box protein H1; FOX H1; FOXH 1; FOXH1; FOXH1_HUMAN; hFAST 1; hFAST-1; hFAST1; Human homolog of Xenopus forkhead activin signal transducer 1; TGF beta/Activin signal transducer FAST1
種屬：

Homo sapiens (Human)
蛋白長度：

Full length protein
表達區域：

1-365
氨基酸序列

MGPCSGSRLG PPEAESPSQP PKRRKKRYLR HDKPPYTYLA MIALVIQAAP SRRLKLAQII RQVQAVFPFF REDYEGWKDS IRHNLSSNRC FRKVPKDPAK PQAKGNFWAV DVSLIPAEAL RLQNTALCRR WQNGGARGAF AKDLGPYVLH GRPYRPPSPP PPPSEGFSIK SLLGGSGEGA PWPGLAPQSS PVPAGTGNSG EEAVPTPPLP SSERPLWPLC PLPGPTRVEG ETVQGGAIGP STLSPEPRAW PLHLLQGTAV PGGRSSGGHR ASLWGQLPTS YLPIYTPNVV MPLAPPPTSC PQCPSTSPAY WGVAPETRGP PGLLCDLDAL FQGVPPNKSI YDVWVSHPRD LAAPGPGWLL SWCSL
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 668
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Transcriptional activator. Recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3'. Required for induction of the goosecoid (GSC) promoter by TGF-beta or activin signaling. Forms a transcriptionally active complex containing FOXH1/SMAD2/SMAD4 on a site on the GSC promoter called TARE (TGF-beta/activin response element).
基因功能參考文獻：
1. These results indicate that Smad4 acts as a tumor suppressor by activating FOXH1, and then suppressing the expression of estrogen receptor, in addition to tumor migration and invasion. PMID: 25482028
2. HEB and E2A-bind the SCA motif at regions overlapping SMAD2/3 and FOXH1 PMID: 21828274
3. Four genetic variants are found in FOXH1 that are associated with ventricular septal defects in Chinese patients. PMID: 19525021
4. Results suggest that PKA can negatively regulate ERalpha, at least in part, through FoxH1. PMID: 19711044
5. This work suggests that FAST-1 may participate in the vascular smooth muscle response to injury and may represent a potential molecular target for modulating the progression of cardiac allograft vasculopathy. PMID: 15737749
6. Smad-binding peptide aptamer FOXH1 can be developed to selectively inhibit TGF-beta-induced gene expression. PMID: 15750622
7. These results demonstrate for a functional role for TGF-beta ligands in regulation of mammalian Mixl1, identify FoxH1 as an essential co-activator, and implicate Nodal as the embryonic regulator of Mixl1 in mesendoderm morphogenesis. PMID: 15982639
8. FoxH1 has a role in androgen receptor-mediated transactivation PMID: 16120611
9. Reduced NODAL signaling via mutation of several pathway members including FOXH1 is linked to heart defects and holoprosencephaly. PMID: 18538293
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亞細胞定位：

Nucleus.
組織特異性：

Ubiquitous.
數據庫鏈接：

HGNC: 3814

OMIM: 603621

KEGG: hsa:8928

STRING: 9606.ENSP00000366534

UniGene: Hs.708365