Recombinant Human Cadherin EGF LAG seven-pass G-type receptor 3 (CELSR3), partial

中文名稱：

Recombinant Human Cadherin EGF LAG seven-pass G-type receptor 3(CELSR3) ,partial
貨號：

CSB-YP865181HU
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Human Cadherin EGF LAG seven-pass G-type receptor 3(CELSR3) ,partial
貨號：

CSB-EP865181HU
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Human Cadherin EGF LAG seven-pass G-type receptor 3(CELSR3) ,partial
貨號：

CSB-EP865181HU-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Human Cadherin EGF LAG seven-pass G-type receptor 3(CELSR3) ,partial
貨號：

CSB-BP865181HU
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Human Cadherin EGF LAG seven-pass G-type receptor 3(CELSR3) ,partial
貨號：

CSB-MP865181HU
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
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靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

CELSR3
Uniprot No.：

Q9NYQ7
別名：

Anchor protein; Cadherin EGF LAG seven-pass G-type receptor 3; Cadherin family member 11; CDHF11; CELR3_HUMAN; Celsr3; EGF like domain multiple 1; EGF-like protein 1; EGFL1; Epidermal growth factor-like protein 1; Flamingo; Flamingo homolog 1; FMI1; hFmi1; MEGF2; Multiple EGF-like domains protein 2; Multiple epidermal growth factor-like domains protein 2; RESDA1
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Receptor that may have an important role in cell/cell signaling during nervous system formation.
基因功能參考文獻：
1. Study identifies four likely Tourette disorder risk genes with multiple de novo damaging variants in unrelated probands: WWC1 (WW and C2 domain containing 1), CELSR3 (Cadherin EGF LAG seven-pass G-type receptor 3), NIPBL (Nipped-B-like), and FN1 (fibronectin 1). PMID: 28472652
2. marked reduction in the prominence of TUJ1 bundles in number, thickness, and length. Our results showed that deregulation of the planar cell polarity genes CELSR3 and FZD3 might disrupt the enteric innervation pattern PMID: 27619161
3. A moderate positive correlation between CELSR3 and patient age was also evident. PMID: 26838213
4. seven-transmembrane domain receptors Celsr3 and Fzd3, in particular, control the development of most longitudinal tracts in the central nervous system. [Review] PMID: 25813877
5. CELSR3 promoter hypermethylation is associated with oral squamous cell carcinoma. PMID: 25374236
6. CELSR3 was found to be selectively up-regulated in tumor stellate cells. PMID: 20416094
7. CELSR3 is one of the core PCP signaling molecules. PMID: 16273260
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亞細胞定位：

Cell membrane; Multi-pass membrane protein.
蛋白家族：

G-protein coupled receptor 2 family, LN-TM7 subfamily
數據庫鏈接：

HGNC: 3230

OMIM: 604264

KEGG: hsa:1951

STRING: 9606.ENSP00000164024

UniGene: Hs.631926