Recombinant Human Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 (ASAP3), partial

中文名稱：

Recombinant Human Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3(ASAP3) ,partial
貨號：

CSB-YP837444HU
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Human Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3(ASAP3) ,partial
貨號：

CSB-EP837444HU
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Human Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3(ASAP3) ,partial
貨號：

CSB-EP837444HU-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Human Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3(ASAP3) ,partial
貨號：

CSB-BP837444HU
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Human Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3(ASAP3) ,partial
貨號：

CSB-MP837444HU
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

ASAP3
Uniprot No.：

Q8TDY4
別名：

9430088F20Rik; ACAP4; ANK repeat and PH domain-containing protein 3; Arf GAP with SH3 domain; Arf GAP with SH3 domain; ANK repeat and PH domain containing protein 3; Arf-GAP with SH3 domain; ARF6 GTPase activating protein; ArfGAP with SH3 domain; ankyrin repeat and PH domain ; ArfGAP with SH3 domain; ankyrin repeat and PH domain 3 1; ASAP3; ASAP3_HUMAN; BOS_2358; Centaurin; beta 6; CENTB6; DDEFL1; Development and differentiation enhancing factor like 1; Development and differentiation-enhancing factor-like 1; FLJ20199; Gm140; MGC102639; MGC155101; OTTMUSP00000010435; Protein up-regulated in liver cancer 1; RP23-118A9.4; Up regulated in liver cancer 1 (UPLC1); UPLC1
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Promotes cell proliferation.
基因功能參考文獻：
1. Results show that ASAP3 was amplified in colorectal cancer (CRC) tissues, and its upregulation was associated with poor prognosis of patients with CRC. Also, it promoted growth of colon tumors, and accelerated cell invasion and migration through its binding to NEMO. These results suggest that ASAP3 acts as an oncogene. PMID: 28502111
2. The data, for the first time, link ASAP3 with ACTG1 in the regulation of cytoskeletal maintenance and cell motility PMID: 24284654
3. ). These data indicate that ASAP3 is elevated in NSCLC and may contribute to cancer development and patients' poor clinical outcome, which is possibly due to its critical roles in regulating cancer invasion. PMID: 24078447
4. Phosphorylation of the N-terminal region of ACAP4 (named the Bin, Amphiphysin, and RSV161/167[BAR] domain at Tyr34) is necessary for epidermal growth factor (EGF)-elicited membrane remodeling. PMID: 23776207
5. ACAP4 protein cooperates with Grb2 protein to orchestrate epidermal growth factor-stimulated integrin beta1 recycling in cell migration PMID: 22027826
6. The ArfGAP catalytic mechanism and shows a glutamine from Arf6 and an arginine fingerASAP3 as the important catalytic residues; unexpectedly the structure shows a calcium ion, liganded by both proteins in the complex interface. PMID: 20510928
7. ACAP4 is involved in ARF6-mediated cell migration. PMID: 16737952
8. ASAP3 functions nonredundantly with ASAP1 to control cell movement and may have a role in cancer cell invasion. PMID: 18400762
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亞細胞定位：

Cytoplasm.
組織特異性：

Highly expressed in primary hepatocarcinoma. Detected in lung, liver and blood leukocytes.
數據庫鏈接：

HGNC: 14987

OMIM: 616594

KEGG: hsa:55616

STRING: 9606.ENSP00000338769

UniGene: Hs.437379