Recombinant Human ATP synthase subunit epsilon, mitochondrial (ATP5E)

中文名稱：

Recombinant Human ATP synthase subunit epsilon, mitochondrial(ATP5E)
貨號：

CSB-YP002356HU
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Human ATP synthase subunit epsilon, mitochondrial(ATP5E)
貨號：

CSB-EP002356HU
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Human ATP synthase subunit epsilon, mitochondrial(ATP5E)
貨號：

CSB-EP002356HU-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Human ATP synthase subunit epsilon, mitochondrial(ATP5E)
貨號：

CSB-BP002356HU
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Human ATP synthase subunit epsilon, mitochondrial(ATP5E)
貨號：

CSB-MP002356HU
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

ATP5E
Uniprot No.：

P56381
別名：

ATP5F1E; ATP5EATP synthase subunit epsilon; mitochondrial; ATPase subunit epsilon; ATP synthase F1 subunit epsilon
種屬：

Homo sapiens (Human)
蛋白長度：

Full Length of Mature Protein
表達區域：

2-51
氨基酸序列

VAYWRQAGL SYIRYSQICA KAVRDALKTE FKANAEKTSG SNVKIVKVKK E
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.
基因功能參考文獻：
1. ATP5E transcript alteration (down-expression) was highly associated to PTC diagnosis PMID: 26079849
2. The cell surface F1/F0 ATP synthase complex plays a key role in the acidic microenvironment of tumor tissues. PMID: 24067918
3. the epsilon subunit is essential for the assembly of F1 and plays an important role in the incorporation of the hydrophobic subunit c into the F1-c oligomer rotor of the mitochondrial ATP synthase complex PMID: 20026007
4. Galectin 3 co-localized with ATP synthase in the inner membrane of mitochondria and had an inhibitory effect on ATP synthase in human colon cancer cells. PMID: 19016746
相關疾病：

Mitochondrial complex V deficiency, nuclear 3 (MC5DN3)
亞細胞定位：

Mitochondrion. Mitochondrion inner membrane.
蛋白家族：

Eukaryotic ATPase epsilon family
組織特異性：

Ubiquitous.
數據庫鏈接：

HGNC: 838

OMIM: 606153

KEGG: hsa:514

STRING: 9606.ENSP00000243997

UniGene: Hs.177530