Recombinant Human A disintegrin and metalloproteinase with thrombospondin motifs 17 (ADAMTS17), partial

中文名稱：

Recombinant Human A disintegrin and metalloproteinase with thrombospondin motifs 17(ADAMTS17) ,partial
貨號：

CSB-YP848415HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Human A disintegrin and metalloproteinase with thrombospondin motifs 17(ADAMTS17) ,partial
貨號：

CSB-EP848415HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Human A disintegrin and metalloproteinase with thrombospondin motifs 17(ADAMTS17) ,partial
貨號：

CSB-EP848415HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Human A disintegrin and metalloproteinase with thrombospondin motifs 17(ADAMTS17) ,partial
貨號：

CSB-BP848415HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Human A disintegrin and metalloproteinase with thrombospondin motifs 17(ADAMTS17) ,partial
貨號：

CSB-MP848415HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

ADAMTS17
Uniprot No.：

Q8TE56
別名：

A disintegrin and metalloproteinase with thrombospondin motifs 17; A disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif; 17; ADAM metallopeptidase with thrombospondin type 1 motif; 17; ADAM-TS 17; ADAM-TS17; ADAMTS 17; ADAMTS-17; ADAMTS17; ATS17_HUMAN; EC 3.4.24.; FLJ16363; FLJ32769; OTTHUMP00000194818
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

基因功能參考文獻：
1. Secretion of ADAMTS17 requires O-fucosylation. ADAMTS17 binds fibrillin-2 but not fibrillin-1 and does not cleave either. ADAMTS17 regulates fibrillin isoform composition of microfibrils in the eye. PMID: 28176809
2. higher Adamts17 expression is found in several human cancer cell subtypes, especially in breast ductal carcinoma and there is an inverse correlation between higher Adamts17 expression and patients' survival. PMID: 24906090
3. The mutation in the Weill-Marchesani syndrome (WMS)- gene ADAMTS17 also causes WMS in an Indian family. PMID: 24940034
4. A mutation in WMS-like gene ADAMTS17 also causes WMS. PMID: 24940034
5. Endothelial protease nexin-1 is a novel regulator of A disintegrin and metalloproteinase 17 maturation and endothelial protein C receptor shedding via furin inhibition. PMID: 23661674
6. Recessive ADAMTS17 mutations are a recurrent cause of isolated spherophakia with short stature. PMID: 22486325
7. ADAMTS17 is a target gene of the BACH1 transcription factor according to ChIP-seq analysis in HEK 293 cells. PMID: 21555518
8. Homozygous mutation in ADAMTS17 causes lenticular myopia, ectopia lentis, glaucoma, spheropakia, and short stature. PMID: 19836009
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相關疾病：

Weill-Marchesani-like syndrome (WMSL)
亞細胞定位：

Secreted, extracellular space, extracellular matrix.
組織特異性：

Isoform 1 and isoform 2 are expressed at high levels in the lung, brain, whole eye and retina. Isoform 1 shows a weaker expression in the heart, kidney and skeletal muscle. Isoform 2 shows a weaker expression in the kidney, bone marrow and skeletal muscle
數據庫鏈接：

HGNC: 17109

OMIM: 607511

KEGG: hsa:170691

STRING: 9606.ENSP00000268070

UniGene: Hs.513200