Recombinant Human 17-beta-hydroxysteroid dehydrogenase 13 (HSD17B13)

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中文名稱：

人HSD17B13重組蛋白
貨號：

CSB-EP801815HUc7
說明書：

MSDS Datasheet
規(guī)格：

￥1836
圖片：
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
其他：

產(chǎn)品詳情
產(chǎn)品評價
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靶點詳情

產(chǎn)品詳情

純度：

Greater than 85% as determined by SDS-PAGE.
生物活性：

Not Test
基因名：

HSD17B13
Uniprot No.：

Q7Z5P4
別名：

(17-beta-HSD 13)(Short chain dehydrogenase/reductase family 16C member 3)(Short-chain dehydrogenase/reductase 9)
種屬：

Homo sapiens (Human)
蛋白長度：

Full Length of Mature Protein of Isoform 2
來源：

E.coli
分子量：

32.4
表達區(qū)域：

20-300aa
氨基酸序列

ESLVKFFIPQRRKSVAGEIVLITGAGHGIGRQTTYEFAKRQSILVLWDINKRGVEETAAECRKLGVTAHAYVVDCSNREEIYRSLNQVKKEVGDVTIVVNNAGTVYPADLLSTKDEEITKTFEVNILGHFWITKALLPSMMERNHGHIVTVASVCGHEGIPYLIPYCSSKFAAVGFHRGLTSELQALGKTGIKTSCLCPVFVNTGFTKNPSTRLWPVLETDEVVRSLIDGILTNKKMIFVPSYINIFLRLQKFLPERASAILNRMQNIQFEAVVGHKIKMK
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

C-terminal 6xHis-tagged
產(chǎn)品提供形式：

Liquid or Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

3-7 business days
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Datasheet & COA：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

基因功能參考文獻：
1. Lower HSD17B13 in peritumoral tissues was associated with worse recurrence free survival and overall survival of hepatocellular carcinoma patients and altered G1/S progression of HCC cells. PMID: 29748147
2. We conducted a test for association between the rs72613567:TA variant and protection against severe liver fibrosis in 88 patients of Caucasian descent with HCV monoinfection. We conclude that rs72613567:TA is correlated with protection against liver fibrosis associated with HCV infection. PMID: 30403944
3. A loss-of-function variant in HSD17B13 was associated with a reduced risk of chronic liver disease and of progression from steatosis to steatohepatitis. PMID: 29562163
4. 17beta-HSD13 as a pathogenic protein in the development of nonalcoholic fatty liver disease. PMID: 25028495
5. A new human short-chain dehydrogenase/reductase gene SCDR9 is cloned and expressed. PMID: 17311113
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亞細胞定位：

Endoplasmic reticulum. Lipid droplet.
蛋白家族：

Short-chain dehydrogenases/reductases (SDR) family
組織特異性：

Highly expressed in the liver. Also detected in ovary, bone marrow, kidney, brain, lung, skeletal muscle, bladder and testis.
數(shù)據(jù)庫鏈接：

HGNC: 18685

OMIM: 612127

KEGG: hsa:345275

STRING: 9606.ENSP00000333300

UniGene: Hs.284414