Recombinant Dog Breast cancer type 1 susceptibility protein homolog (BRCA1), partial

中文名稱：

Recombinant Dog Breast cancer type 1 susceptibility protein homolog(BRCA1) ,partial
貨號：

CSB-YP839156DO
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Dog Breast cancer type 1 susceptibility protein homolog(BRCA1) ,partial
貨號：

CSB-EP839156DO
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Dog Breast cancer type 1 susceptibility protein homolog(BRCA1) ,partial
貨號：

CSB-EP839156DO-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Dog Breast cancer type 1 susceptibility protein homolog(BRCA1) ,partial
貨號：

CSB-BP839156DO
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Dog Breast cancer type 1 susceptibility protein homolog(BRCA1) ,partial
貨號：

CSB-MP839156DO
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

BRCA1
Uniprot No.：

Q95153
別名：

BRCA1Breast cancer type 1 susceptibility protein homolog; EC 2.3.2.27; RING-type E3 ubiquitin transferase BRCA1
種屬：

Canis familiaris (Dog) (Canis lupus familiaris)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Required for FANCD2 targeting to sites of DNA damage. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation. Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks. Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8. Acts as a transcriptional activator.
基因功能參考文獻：
1. Three previously unreported single-nucleotide polymorphisms in BRCA1 in canine mammary tumors are reported. PMID: 26156012
2. 46.7% of the malignant mammary tumors were found with a deletion of one cytosine in the promoter region. mRNA expression of BRCA1 was significantly reduced in benign and malignant mammary tumors. PMID: 26679809
3. one SNP in exon 9 of BRCA1 and one SNP in exon 24 of BRCA2 were found to be significantly associated with canine mammary tumours PMID: 24122022
4. The expression of multiple splice variants of BRCA1 in mammary gland tumors of dogs is reported. PMID: 17611353
5. this study indicates that BRCA1 and BRCA2 contribute to the risk of canine mammary tumors in English springer spaniels PMID: 19887619
6. The amino terminal RING finger motif and the granin consensus sequence are conserved between human, canine, and murine BRCA1 genes. PMID: 8872468
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亞細胞定位：

Nucleus. Chromosome. Cytoplasm.
數據庫鏈接：

KEGG: cfa:403437

STRING: 9615.ENSCAFP00000021534

UniGene: Cfa.140