Recombinant Chicken Calcium-activated potassium channel subunit alpha-1 (KCNMA1), partial

中文名稱：

雞KCNMA1重組蛋白
貨號(hào)：

CSB-YP803832CH
說明書：

MSDS Datasheet
規(guī)格：
來源：

Yeast
其他：

中文名稱：

雞KCNMA1重組蛋白
貨號(hào)：

CSB-EP803832CH
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
其他：

中文名稱：

雞KCNMA1重組蛋白
貨號(hào)：

CSB-EP803832CH-B
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

雞KCNMA1重組蛋白
貨號(hào)：

CSB-BP803832CH
說明書：

MSDS Datasheet
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

雞KCNMA1重組蛋白
貨號(hào)：

CSB-MP803832CH
說明書：

MSDS Datasheet
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

KCNMA1
Uniprot No.：

Q8AYS8
別名：

KCNMA1; KCNMACalcium-activated potassium channel subunit alpha-1; BK channel; BKCA alpha; Calcium-activated potassium channel; subfamily M subunit alpha-1; K(VCA)alpha; KCa1.1; Maxi K channel; MaxiK; Slo-alpha; Slo1; Slowpoke homolog; Slo homolog; cSlo
種屬：

Gallus gallus (Chicken)
蛋白長度：

Partial
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. In smooth muscles, its activation by high level of Ca(2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX).
基因功能參考文獻(xiàn)：
1. findings suggest that palmitoylation of the STREX domain is necessary for cerebrosides to activate the BKCa channel PMID: 24946143
2. These studies identify for the first time a central role for beta-catenin in mediating Slo surface expression. PMID: 22194818
3. This comparative systems approach suggests conservation in BK function across different species in addition to novel functions that may include the initiation of signals relevant to cell death/survival. PMID: 22174833
4. Currents from the alpha (Slo)-subunit of hair- cell BK channel alone do not show dramatic increases in response to changes in divalent calcium ion (Ca2+) concentrations at -50 millivolts expressed in low-frequency hair cells. PMID: 21178105
5. These results indicate that delays in protein synthesis and trafficking/scaffolding of channel subunits underlie the late acquisition of BK currents in cochlear hair cells. PMID: 20503427
6. The present results suggest that axial stretch activates BK(Ca) channels via a stretch-induced increase in the cytosolic Na(+) concentration followed by an increased Ca(2+) influx. PMID: 20176677
7. By analyzing the complete sequences of cSlo cDNAs from the cochlea, we show that most transcripts lack alternative exons. Transcripts with more than one alternative exon constitute only 10% of the total. PMID: 20479127
8. MAGI-1 interacts with Slo1 channel proteins and suppresses Slo1 expression on the cell surface. PMID: 19403801
9. Tamoxifen inhibits BK channels in chick cochlea without alterations in voltage-dependent activation. PMID: 19439526
10. These results suggest that SAK(CA) senses membrane tension through an interaction between STREX and submembranous components. PMID: 19482008
顯示更多

收起更多
亞細(xì)胞定位：

Membrane; Multi-pass membrane protein.
蛋白家族：

Potassium channel family, Calcium-activated (TC 1.A.1.3) subfamily, KCa1.1/KCNMA1 sub-subfamily
數(shù)據(jù)庫鏈接：

KEGG: gga:374065

STRING: 9031.ENSGALP00000007968

UniGene: Gga.3260