Recombinant Ceratogyrus marshalli Beta-theraphotoxin-Cm1a

中文名稱：

Recombinant Ceratogyrus marshalli Beta-theraphotoxin-Cm1a
貨號：

CSB-YP308058CGN
說明書：

MSDS Datasheet
規(guī)格：
來源：

Yeast
其他：

中文名稱：

Recombinant Ceratogyrus marshalli Beta-theraphotoxin-Cm1a
貨號：

CSB-EP308058CGN
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
其他：

中文名稱：

Recombinant Ceratogyrus marshalli Beta-theraphotoxin-Cm1a
貨號：

CSB-EP308058CGN-B
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Ceratogyrus marshalli Beta-theraphotoxin-Cm1a
貨號：

CSB-BP308058CGN
說明書：

MSDS Datasheet
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Ceratogyrus marshalli Beta-theraphotoxin-Cm1a
貨號：

CSB-MP308058CGN
說明書：

MSDS Datasheet
規(guī)格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

N/A
Uniprot No.：

P84507
別名：

; Beta-theraphotoxin-Cm1a; Beta-TRTX-Cm1a; CcoTx-I; Ceratotoxin-1; CcoTx1
種屬：

Ceratogyrus marshalli (Straighthorned baboon tarantula) (Ceratogyrus cornuatus)
蛋白長度：

Cytoplasmic domain
表達區(qū)域：

1-33
氨基酸序列

DCLGWFKSCD PKNDKCCKNY TCSRRDRWCK YDL
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Inhibits many voltage-gated sodium channels and one voltage-gated calcium channel (Cav2.2/CACNA1B (IC(50)=400 nM), Nav1.2/SCN2A (IC(50)=3-70 nM), Nav1.1/SCN1A (IC(50)=523-1060 nM), Nav1.7/SCN9A (IC(50)=129.1-5120 nM), Nav1.4/SCN4A (IC(50)=263-888 nM or >10 uM) and Nav1.5/SCN5A (IC(50)=188-323 nM or >10 uM)). It acts by shifting the voltage dependence of channel activation to more depolarized potentials and by blocking the inward component of the sodium current. It shows moderate affinity for lipid bilayers. On Nav1.7/SCN9A, it has been shown to interact with the S3-S4 loop of domain DII (site 4). Is significantly more potent against Nav1.2/SCN2A than the other Nav channel subtypes. In vivo, this toxin causes general ataxia, lack of response to stimuli, and semiparalysis. After a few minutes, the mice are unable to stand, and breathing is reduced in rhythm and intensity. Symptoms gradually increase with progressive slowing of breathing and flaccid paralysis, death occurred within 10 to 20 minutes post injection. Animals remain totally flaccid, and no symptoms of excitatory neurotoxicity are observed.
亞細胞定位：

Secreted.
蛋白家族：

Huwentoxin-1 family, CcoTx1 subfamily
組織特異性：

Expressed by the venom gland.