TM4SF1 Recombinant Monoclonal Antibody
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中文名稱：TM4SF1重組抗體
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貨號：CSB-RA023615MA1HU
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規(guī)格：￥1320
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圖片：
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The Binding Activity of Human TM4SF1 with Anti-TM4SF1 recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human TM4SF1(CSB-MP023615HU) at 5 μg/mL can bind Anti-TM4SF1 recombinant antibody. the EC50 is 4.079-4.472 ng/mL.
The VLPs (CSB-MP3838) is negative control. -
Untransfected CT26 cells (green line) and transfected Human TM4SF1*106cells), washed and then followed by APC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.
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其他：
產(chǎn)品詳情
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產(chǎn)品描述：CSB-RA023615MA1HU TM4SF1重組單克隆抗體是針對四次跨膜蛋白超家族成員TM4SF1開發(fā)的高特異性科研試劑。該跨膜蛋白通過調(diào)控細(xì)胞遷移、增殖和信號傳導(dǎo)通路，在腫瘤血管生成及轉(zhuǎn)移過程中發(fā)揮重要作用，尤其在肝細(xì)胞癌、結(jié)直腸癌等多種實(shí)體瘤中呈現(xiàn)顯著高表達(dá)特征。本產(chǎn)品采用重組表達(dá)技術(shù)制備，經(jīng)ELISA方法嚴(yán)格驗(yàn)證，展現(xiàn)出優(yōu)異的抗原結(jié)合能力和穩(wěn)定的批次重復(fù)性，適用于體外實(shí)驗(yàn)體系中目標(biāo)蛋白的檢測分析。科研人員可利用該抗體開展TM4SF1在腫瘤微環(huán)境中的功能機(jī)制研究，包括通過ELISA技術(shù)定量檢測細(xì)胞培養(yǎng)上清或組織裂解液中的蛋白表達(dá)水平，為探究腫瘤發(fā)生發(fā)展相關(guān)分子通路提供可靠工具，同時(shí)也可作為研究腫瘤細(xì)胞表面標(biāo)志物的基礎(chǔ)試劑，應(yīng)用于癌癥生物學(xué)領(lǐng)域的體外實(shí)驗(yàn)研究。
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Uniprot No.：
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基因名：
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別名：TM4SF1 Recombinant Monoclonal Antibody
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反應(yīng)種屬：Human
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免疫原：Recombinant Human TM4SF1 protein
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Non-conjugated
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克隆類型：Monoclonal
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抗體亞型：hIgG1
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純化方式：Affinity-chromatography
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克隆號：6B3
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA, FC
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推薦稀釋比：
Application Recommended Dilution FC 1:20-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
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靶點(diǎn)詳情
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基因功能參考文獻(xiàn)：
- our study provides a novel regulatory pathway involving TM4SF1, DDR1, MMP2 and MMP9, which promotes the formation and function of invadopodia to support cell migration and invasion in pancreatic cancer. PMID: 28368050
- Regulation of transmembrane-4-L-six-family-1 (TM4SF1) on bladder cancer cell could be induced by peroxisome proliferator-activated receptor gamma (PPARgamma)-sirtuin 1 (SIRT1) feedback loop. PMID: 29175458
- TM4SF1 was recognized as a direct target for miR-520f in hepatocellular carcinoma (HCC) cells where its expression was found up-regulated and inversely correlated with that of mir-520f. PMID: 29505836
- Results suggest that miR-30a is an important regulator of TM4SF1, VEGF, and E-cadherin for CRC lymph node metastasis, a potential new therapeutic target in CRC. PMID: 28528497
- High TM4SF1 expression is associated with esophageal cancer. PMID: 27974706
- Replacement of the transmembrane 4 L six family protein TM4SF1 or TM4SF4 C-terminus with that of TM4SF5 increased spheroids growth, transwell migration, and invasive dissemination from spheroids in 3D collagen gels. PMID: 28129652
- Results indicate that the expression of transmembrane 4 L6 family member 1 (TM4SF1) is higher in pancreatic cancer tissues and pancreatic cancer cell lines than controls. PMID: 27459514
- Results show that TM4SF1 expression is elevated in colorectal cancer (CRC), and associated with tumor stage and lymph node metastasis. Also, miR-9 directly targeted its binding site in the TM4SF1 3'-UTR, which has a critical role in regulating CRC cell migration. and invasion. Furthermore, miR-9 regulated cell motility via suppressing PMID: 26983891
- The findings suggest that TM4SF1 is a surface membrane antigen that is highly expressed in pancreatic cancer cells and increases the chemoresistance to gemcitabine. TM4SF1 may be a promising target to overcome the chemoresistance of pancreatic cancer. PMID: 26709920
- TM4SF1 overexpression significantly contributed MDA-MB-231 cell migration but decreased apoptotic cells PMID: 26464650
- Study shows that TM4SF1 expression is associated with better prognosis in pancreatic cancer. Its loss contributes to the invasion and migration of pancreatic cancer cells. PMID: 26035794
- We found that miR-203 was significantly downregulated in OSF tissues compared to that in normal buccal mucosa tissues, and that miR-203 negatively regulated secreted SFRP4 and positively regulated TM4SF1 PMID: 25872484
- Transmembrane-4-L-six-family-1 is overexpressed in human gliomas in general and the precise level of expression might predict outcome and could be of clinical value. PMID: 25855954
- These findings validate TM4SF1 as an attractive candidate for cancer therapy with antibody-bound toxins that have the capacity to react with either cytoplasmic or nuclear targets in tumor cells or tumor-associated vascular endothelium. PMID: 26241677
- TM4SF1 is a small plasma membrane glycoprotein that regulates cell motility and proliferation, and possibly a new vascular therapeutic target in cancer PMID: 24986520
- High TM4SF1 expression is associated with pancreatic cancer. PMID: 24285464
- TM4SF1, like genuine tetraspanins, serves as a molecular organizer that interacts with membrane and cytoskeleton-associated proteins and uniquely initiates the formation of nanopodia and facilitates cell polarization and migration. PMID: 21626280
- We provide evidence that ARHGDIA, COBLL1, and TM4SF1 are negative regulators of apoptosis in cultured tumor cells. PMID: 21569526
- Inhibition of cell migration after targeted knockdown of TM4SF1 protein expression suggests its contribution to prostate cancer cell metastasis. PMID: 21656834
- TM4SF1 can serve as a surface protein marker which singly identifies MSCs from diverse cell sources, in particular, fibroblast-rich connective tissues PMID: 20486778
- TAL6 may play a role in cancer invasion and metastasis PMID: 12855661
- These data suggest that L6-Ag influences cell motility via TERM by regulating the surface presentation and endocytosis of some of their components. PMID: 18270265
- The gene ratio test with the TM4SF1 gene for survival of patients with malignant pleural mesothelioma has robust predictive value. PMID: 19401544
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亞細(xì)胞定位：Membrane; Multi-pass membrane protein.
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蛋白家族：L6 tetraspanin family
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組織特異性：Highly expressed in lung, breast, colon and ovarian carcinomas. It is also present on some normal cells, endothelial cells in particular.
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數(shù)據(jù)庫鏈接：
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