PGM1 Recombinant Monoclonal Antibody

說明書

中文名稱：

PGM1 Recombinant Monoclonal Antibody
貨號：

CSB-RA964397A0HU
規(guī)格：

￥1320
圖片：
Flow cytometric analysis of phosphoglucomutase 1 expression in HepG2 cells using phosphoglucomutase 1 antibody. Green, isotype control; red, phosphoglucomutase 1.

Immunocytochemical staining of HepG2 cells with phosphoglucomutase 1 antibody. Nuclei were stained blue with DAPI; Phosphoglucomutase 1 was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar: 20 μm.

Western blotting analysis using phosphoglucomutase 1? antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with phosphoglucomutase 1 antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

Uniprot No.：

P36871
基因名：

PGM1
別名：

PGM1; Phosphoglucomutase 1; Glucose Phosphomutase 1; Phosphoglucomutase-1; EC 5.4.2.2; PGM 1; EC 5.4.2; CDG1T; GSD14
反應種屬：

Human, Mouse, Rat
免疫原：

Recombinant Human PGM1 protein
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Monoclonal
抗體亞型：

Rabbit IgG
純化方式：

Affinity-chromatography
克隆號：

16B5
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Rabbit IgG in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
產(chǎn)品提供形式：

Liquid
應用范圍：

ELISA, WB, FC, ICC

推薦稀釋比：

Application	Recommended Dilution
WB	1:1000-1:5000
FC	1:200-1:2000
ICC	1:100-1:1000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Flow cytometry (FC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

This enzyme participates in both the breakdown and synthesis of glucose.
基因功能參考文獻：
1. PGM1 deficiency has been recognized as a cause of the congenital disorders of glycosylation. PMID: 29858906
2. The structural perturbation resulting from mutation of this single amino acid reveals the molecular mechanism underlying PGM1 deficiency in these missense variants. PMID: 28117557
3. Homozygous mutation in the PGM1 gene is associated with PGM1 deficiency. PMID: 26768186
4. analysis of the structural basis of PGM1 enzyme dysfunction in PGM1 deficiency PMID: 26972339
5. both PGM1 protein misfolding and catalytic impairment may play a role in PGM1 deficiency PMID: 25288802
6. PGM1 is required for sustained cell growth during nutritional changes PMID: 24952355
7. Phosphoglucomutase 1 deficiency, previously identified as a glycogenosis, is also a congenital disorder of glycosylation. PMID: 24499211
8. The analysis involved the data on nine polymorphic codominant loci: HP, GC, TF, PI, PGM1, GLO1, C3, ACP1, and ESD. The loci were selected by significance of differences in genotype frequencies between tuberculosis patients and healthy controls PMID: 12942785
9. Results report a novel human protein, calphoglin, which activates inorganic pyrophosphatase (IPP) and enhances phosphoglucomutase activity through the activated IPP. PMID: 15522220
10. During extrauterine life, females carrying the PGM1*2 allele are relatively protected from extreme body mass increase, and during intrauterine life, PGM1*2/*2 homozygotes show a tendency to low body mass increase. PMID: 18091362
11. There is a correlation between glomerular expression of MCP-1 and PGM1 and worsening renal prognosis in paediatric lupus nephritis. PMID: 18495743
12. ZASP/Cypher anchors PGM1 to Z-disc under conditions of stress. The impaired binding of PGM1 to ZASP/Cypher might be involved in the pathogenesis of dilated cardiomyopathy. PMID: 19377068
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相關(guān)疾病：

Congenital disorder of glycosylation 1T (CDG1T)
亞細胞定位：

[Isoform 1]: Cytoplasm.
蛋白家族：

Phosphohexose mutase family
數(shù)據(jù)庫鏈接：

HGNC: 8905

OMIM: 171900

KEGG: hsa:5236

UniGene: Hs.1869

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