MRC1 Recombinant Monoclonal Antibody

說明書

中文名稱：

MRC1 Recombinant Monoclonal Antibody
貨號：

CSB-RA775652A0HU
規格：

￥1320
圖片：
Flow cytometric analysis of Mannose Receptor (CD206) expression in HepG2 cells using Mannose Receptor (CD206) antibody. Green, isotype control; red, Mannose Receptor.

Immunocytochemical staining of HepG2 cells with Mannose Receptor (CD206) antibody. Nuclei were stained blue with DAPI; Mannose Receptor (CD206) was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: High. Scale bar: 20 μm.

Western blotting analysis using Mannose Receptor (CD206) antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with Mannose Receptor (CD206) antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
其他：

產品詳情
產品評價
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靶點詳情

產品詳情

Uniprot No.：

P22897
基因名：

MRC1
別名：

MRC1; Mannose Receptor C-Type 1; CLEC13DL; CLEC13D; BA541I19.1; MRC1L1; CD206; Macrophage Mannose Receptor 1-Like Protein 1; C-Type Lectin Domain Family 13 Member D; Mannose Receptor, C Type 1-Like 1; Macrophage Mannose Receptor ; Human Mannose Receptor; MMR; HMR; C-Type Lectin Domain Family 13 Member D-Like; Macrophage Mannose Receptor; Mannose Receptor, C Type 1; CD206 Antigen
反應種屬：

Human, Mouse, Rat
免疫原：

Recombinant Human MRC1 protein
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Monoclonal
抗體亞型：

Rabbit IgG
純化方式：

Affinity-chromatography
克隆號：

24C3
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Rabbit IgG in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

ELISA, WB, FC, ICC

推薦稀釋比：

Application	Recommended Dilution
WB	1:1000-1:5000
FC	1:200-1:2000
ICC	1:100-1:1000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Flow cytometry (FC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains.; (Microbial infection) Acts as phagocytic receptor for bacteria, fungi and other pathogens.; (Microbial infection) Acts as a receptor for Dengue virus envelope protein E.; (Microbial infection) Interacts with Hepatitis B virus envelope protein.
基因功能參考文獻：
1. Structural Insights into the pH-dependent conformational change and collagen recognition of the human mannose receptor have been reported. PMID: 29225077
2. no significant difference between our population of Egyptian SCD cases and controls regarding CD209 A>G polymorphism. Infections occurred more frequently among the heterozygous genotype (AG) and homozygous genotype (GG) patients. PMID: 29100978
3. A combination of CD68/CD206 density and HBV-positivity improves further predictive value for post-operative recurrence of hepatocellular carcinoma (HCC) . Quantification of CD68/CD206 macrophages and their distribution can be exploited for better postsurgical management of HCC patients. PMID: 28656201
4. The results showed that the small dense LDL particles reduce the MRC1 gene expression levels in the differentiated M2 macrophages from patients with coronary artery disease. Furthermore, they had high inflammatory capacity for the secretion of histamine. PMID: 28059035
5. Soluble CD206 plasma levels in rheumatoid arthritis reflect decrease in disease activity. PMID: 28598681
6. Loss of antral CD206-positive anti-inflammatory macrophages is a key feature in human gastroparesis and it is associates with interstitial cells of Cajal loss. PMID: 28066953
7. The effect of LPS in the expression of CD163 and CD206 on monocytes is not reverted in LPS tolerant cells, and the inhibition of inflammatory cytokines in tolerant cells is not related with modulation of these receptors PMID: 26352275
8. regulatory effect of the mannose receptor (MR) was mediated by a direct interaction with CD45 on the T cell, inhibiting its phosphatase activity, which resulted in up-regulation of CTLA-4 and the induction of T-cell tolerance. Inhibition of CD45 prevented expression of B-cell lymphoma 6 (Bcl-6), a transcriptional inhibitor that directly bound the CTLA-4 promoter and regulated its activity PMID: 27601670
9. 1,25(OH)2D3 upregulates mannose receptor expression and enhances the monocyte/macrophage phagocytic potential in pulmonary tuberculosis. PMID: 27449998
10. Peritoneal dendritic cellss in endometriosis tissue express high levels of MR, which promotes phagocytosis of dead endometrial cells and thereby contributes to the etiology of endometriosis. PMID: 27793384
11. Mannose Receptor and CLEC5A on Macrophage first attracts the Dengue Virus with high avidity, and the virus concurrently interacts with CLEC5A in close proximity to form a multivalent hetero-complex and facilitate CLEC5A-mediated signal transduction. Dengue Virus Infection Is through a Cooperative Interaction between a Mannose Receptor and CLEC5A on Macrophage as a Multivalent Hetero-Complex. PMID: 27832191
12. Our work demonstrates a key role for MR in the modulation of the TLR4-AhR-IDO axis, which has a significant effect on DC behavior and the development of immune responses against allergens. PMID: 26703454
13. MRC1 and S100A9 may contribute to the determination of the mechanisms and screening involved in CRC. PMID: 26682511
14. Findings show that CD206 was highly expressed in the hepatocellular carcinoma (HCC) tissues and indicate that CD206 is a potential biomarker for predicting HCC prognosis. PMID: 26352004
15. Data show that umbilical cord-derived mesenchymal stem cells (UCMSCs) transplantation promoted the expression of CD206 antigen and increased phagocytic activity of macrophages through interleukin-6 (IL-6) in systemic lupus erythematosus (SLE) patients. PMID: 26209923
16. Data indicate that mannose receptor (CD206) is a major binding receptor for gamma-tilmanocept. PMID: 26202986
17. CD206 is a novel biomarker of alternative macrophage activation and treatment outcome in multiple myeloma. PMID: 26169445
18. The genome wide significant association of MRC1 with sCOMP levels was found likely to act independent of osteoarthritis subtypes. PMID: 25057126
19. CD206+ cells differentiate between influenza A (H1N1)pdm09 and seasonal influenza virus in lung tissue of fatal cases PMID: 25614715
20. TAMs phenotypes of glioma samples are the potential biomarkers in assessing the degree of malignancy, tumor invasion, and patient prognosis in clinic. PMID: 25182001
21. Increased expression of CD206 was found in perivascular macrophages from HIV-infected brain. PMID: 25146376
22. MRC-1 SNP, rs691005 was found to be associated with sustained viral response in HCV-1-infected patients; identified an interaction between MRC-1 rs691005 and IL-28B rs8099917 and response PMID: 24969847
23. presence of soluble form of MR in human serum in critical illness PMID: 24114918
24. There was a significant negative correlation between the number of CD163(+), CD204(+) or CD206(+) alveolar macrophages. PMID: 24498098
25. The MRC1/CD68 ratio is positively associated with adipose tissue lipogenesis and with muscle mitochondrial gene expression in humans. PMID: 23951013
26. Novel MRC1 gene polymorphisms are associated with susceptibility to pulmonary tuberculosis in Chinese Uygur and Kazak populations. PMID: 23653008
27. confers responsivenes to CpG-motif containing oligodeoxynucleotides in macrophages PMID: 24184555
28. Data suggest a role for CD206 in regulating allergen induced allergic responses in asthma. PMID: 23734186
29. Report CD44/macrophage mannose receptor as a ligand/receptor pair involved in the process of lymphocyte transit via the lymphatic vasculature. PMID: 23603511
30. The presence of human mannose receptor in a smaller number of vaginal epithelial cells of serodiscordant females prevented binding and HIV entry into these cells and therefore prevented sexual transmission of HIV. PMID: 23148569
31. The molecular association of the macrophage mannose receptor (MR) with HSP70 family members via the receptor cytoplasmic tail may contribute to MR trafficking in macrophages. PMID: 23345393
32. The mannose receptor found on the novel hybridoma cell has endocytic characteristics consistent with and similar to the mannose receptor found on the surface of monocyte-derived human macrophages. PMID: 22967244
33. results failed to confirm the reported association between MRC1 variant rs1926736 and IFNG variant rs2430561 and leprosy in Han Chinese; however variants rs692527 and rs34856358 of the MRC1 gene were associated with paucibacillary leprosy and rs3138557 of the IFNG gene was significantly associated with multibacillary leprosy PMID: 22392581
34. elderly subjects had twofold higher CD68 and CD206 gene expression (both P < 0.002) than young participants. In both studies, CD68(+) muscle macrophages were not associated with BMI PMID: 22314623
35. The frequency of MRC1 allele G1186A (rs34039386)in a Chinese population was higher in the pulmonary tuberculosis group than controls. No association was found for G1195A, T1212C, C1221G, C1303T or C1323T. PMID: 22393309
36. Sugar moieties on ADAMTS13 interact with MR, thereby promoting its endocytosis by antigen presenting cells. PMID: 22289891
37. MMR distribution in liver, spleen, lung, kidney, heart, diaphragm, quadriceps, and triceps in these animal models and compared them with MMR distribution in wild-type mice. PMID: 21416197
38. Studies show that tumoral mucin-mediated ligation of the MR on infiltrating TAM may contribute to their immune suppressive phenotype. PMID: 21331365
39. The studies provide the first demonstration of a significant role for mannose receptor, synergistic with TLR2, in activating a proinflammatory response to P. aeruginosa infection. PMID: 19197942
40. These data suggest that in hepatitis B virus infected patients, mannose receptor-mediated interaction between HBsAg and dendritic cells and subsequent impairment of dendritic cells predominantly occurs at the main site of infection, the liver. PMID: 19683778
41. This is the first study to imply that genetic variants in MRC1, a major member of the C-type lectin, contribute to the development of sarcoidosis. PMID: 21029423
42. MR plays a key role in the T helper type (Th)2 cell polarization observed after dust mite glycoallergen Der p 1 exposure through regulation of indoleamine 2,3-dioxygenase activity. PMID: 20610655
43. Data identify a new molecular pathway that links engagement of the mannose receptor, an important pattern recognition receptor for M. tuberculosis, with PPARgamma activation, which regulates the macrophage inflammatory response. PMID: 20554962
44. The mannose receptor and hCG were colocalized on the surface of uterine natural killer cells. PMID: 19196802
45. A significant association of exon 7 encoded amino acid haplotypes with leprosy per se (P = 0.012) and multibacillary leprosy (P = 0.004). PMID: 20035344
46. Results suggest that sequence variations in the MRC1 gene are associated with the development of asthma in two independent and ethnically diverse populations. PMID: 19902202
47. reduced expression in Mycobacterium tuberculosis-infected human macrophages exhibiting enhanced cellular adhesion PMID: 12368450
48. Engagement of the endocytic C-type 1 mannose receptor elicits a secretory program in dendritic cells characterized by a repertoire of anti-inflammatory cytokines and chemokines and the ability to inhibit the generation of Th1-polarized immune responses. PMID: 14568928
49. alveolar macrophage mannose receptor mediates Pneumocystis mediated NF-kB nuclear translocation and may represent an important mechanism of the host cell response to Pneumocystis infection PMID: 15155616
50. Endocytosis of glycosylated protein by the mannose receptor does not enhance presentation of antigen. The postulated role of the mannose receptor in presentation of glycoprotein-derived antigen is reevaluated in light of these results. PMID: 15190005
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亞細胞定位：

Endosome membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein.
數據庫鏈接：

HGNC: 7228

OMIM: 153618

KEGG: hsa:4360

STRING: 9606.ENSP00000239761

UniGene: Hs.743903

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