GYPC Recombinant Monoclonal Antibody

說明書

中文名稱：

GYPC Recombinant Monoclonal Antibody
貨號：

CSB-RA959582A0HU
規(guī)格：

￥1320
圖片：
Immunocytochemical staining of HAP-1 cells with Glycophorin C antibody. Nuclei were stained blue with DAPI;Glycophorin C was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar, 20 μm.

Western blotting analysis using Glycophorin C antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with Glycophorin C antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

Uniprot No.：

P04921
基因名：

GYPC
別名：

GYPC; Glycophorin C (Gerbich Blood Group); GPC; Sialoglycoprotein D; CD236R; CD236; GYPD; GPD; Glycoprotein Beta; Gerbich Antigen; Glycoconnectin; Glycophorin-C; Glycophorin-D; PAS-2'; GE; Gerbich Blood Group Antigen; Glycophorin D; CD236 Antigen; PAS-2; GLPC; Ge
反應(yīng)種屬：

Human
免疫原：

Recombinant Human GYPC protein
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

Non-conjugated
克隆類型：

Monoclonal
抗體亞型：

Rabbit IgG
純化方式：

Affinity-chromatography
克隆號：

7E8
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Rabbit IgG in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, WB, ICC

推薦稀釋比：

Application	Recommended Dilution
WB	1:1000-1:5000
ICC	1:100-1:1000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

This protein is a minor sialoglycoprotein in human erythrocyte membranes. The blood group Gerbich antigens and receptors for Plasmodium falciparum merozoites are most likely located within the extracellular domain. Glycophorin-C plays an important role in regulating the stability of red cells.
基因功能參考文獻(xiàn)：
1. The authors set out to understand the similarities and differences among the GYPC deletion alleles Yus and Gerbich by positional PCR sequence analysis to identify the breakpoints. They developed a set of diagnostic PCRs that can be used to classify both Yus and Gerbich phenotypic variants on the basis of their nucleotide deletion. The Yus phenotype was defined by 4 different breakpoints and the Ger PMID: 28272739
2. Plasmodium falciparum STEVOR functions as an erythrocyte-binding protein that recognizes Glycophorin C (GPC) on the red blood cell (RBC) surface and that its binding correlates with the level of GPC on the RBC surface. PMID: 25011110
3. Rosetting assays using CD236R knockdown normocytes derived from hematopoietic stem cells further supports the role of glycophorin C as a receptor in P vivax rosette formation. PMID: 24652986
4. Precise definition of the binding site for the EBA-140 ligand on glycophorin C may be important with respect to human erythrocyte invasion inhibition strategies based on a receptor. PMID: 24379273
5. Glycophorin C delta (exon3) is not associated with protection against severe anaemia in Papua New Guinea. PMID: 21061946
6. The Gerbich blood group system PMID: 20932076
7. The molecular evolution of GYPC among the Hominoidea (Greater and Lesser Apes) and the pattern of polymorphism at the locus in a global human sample, were examined. PMID: 19679754
8. Recombinant Ge2, Ge3 & Ge4 antigens were cloned, expressed and purified. Yus and Ge mutants behaved in SDS-PAGE similarly to normal GPC forms with diffuse glycosylation. PMID: 12058555
9. Data show that the receptor for Plasmodium falciparum erythrocyte-binding antigen 140 (EBA140) is glycophorin C (GYPC) and that this interaction mediates a principal P. falciparum invasion pathway into human erythrocytes. PMID: 12469115
10. Glycophorin C is identified as the receptor for PfEBP-2, the erythrocyte binding ligand of Plasmodium falciparum, and the binding domain on GPC is determined to be amino acid residues 14 through 22 within exon 2. PMID: 12576308
11. Neither mutation was associated with altered susceptibility to asymptomatic Plasmodium falciparum or P. vivax infection. Contribution of these erythrocyte polymorphisms to susceptibility to clinical malaria morbidity requires further study. PMID: 14695625
12. A high GYPC gene expression is associated with an unfavorable outcome, in contrast, a high TRIP3 gene expression is associated with a favorable outcome in childhood ALL. PMID: 19149918
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亞細(xì)胞定位：

Cell membrane; Single-pass type III membrane protein. Note=Linked to the membrane via band 4.1.
蛋白家族：

Glycophorin-C family
組織特異性：

Glycophorin-C is expressed in erythrocytes. Glycophorin-D and IsoGPC are ubiquitously expressed.
數(shù)據(jù)庫鏈接：

HGNC: 4704

OMIM: 110750

KEGG: hsa:2995

STRING: 9606.ENSP00000259254

UniGene: Hs.59138

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