GIPR Recombinant Monoclonal Antibody

中文名稱：

GIPR重組抗體
貨號(hào)：

CSB-RA009438MA2HU
規(guī)格：

￥1320
圖片：
Western Blot
Positive WB detected in:Hela whole cell lysate, PC-3 whole cell lysate, U251 whole cell lysate, HepG2 whole cell lysate
All lanes: GIPR antibody at 1:1000
Secondary
Goat polyclonal to human IgG at 1/50000 dilution
Predicted band size: 54 kDa,49 kDa,50 kDa
Observed band size: 54 kDa
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

產(chǎn)品描述：

CSB-RA009438MA2HU GIPR重組單克隆抗體是針對(duì)胃抑制多肽受體（GIPR）開(kāi)發(fā)的高特異性科研工具，該靶點(diǎn)屬于G蛋白偶聯(lián)受體（GPCR）家族，在調(diào)節(jié)胰島素分泌、能量代謝及脂肪儲(chǔ)存中發(fā)揮重要作用，與2型糖尿病、肥胖等代謝性疾病密切相關(guān)。本抗體通過(guò)重組技術(shù)制備，具有高批次一致性，經(jīng)嚴(yán)格驗(yàn)證可應(yīng)用于酶聯(lián)免疫吸附實(shí)驗(yàn)（ELISA）和蛋白質(zhì)免疫印跡（WB），其中WB實(shí)驗(yàn)推薦使用1:500至1:5000的稀釋范圍，實(shí)驗(yàn)結(jié)果可呈現(xiàn)清晰的特異性條帶。該產(chǎn)品適用于探索GIPR在代謝調(diào)控中的分子機(jī)制、評(píng)估受體表達(dá)水平變化及其與疾病關(guān)聯(lián)性研究，也可為開(kāi)發(fā)靶向GIPR通路的新型干預(yù)策略提供實(shí)驗(yàn)支持，廣泛應(yīng)用于細(xì)胞生物學(xué)、分子病理學(xué)及藥理研究等領(lǐng)域，為科研人員提供可靠的數(shù)據(jù)支持。
Uniprot No.：

P48546
基因名：

GIPR
別名：

Gastric inhibitory polypeptide receptor, GIPR
反應(yīng)種屬：

Human
免疫原：

Recombinant Human GIPR protein
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

Non-conjugated
克隆類型：

Monoclonal
抗體亞型：

Human IgG
純化方式：

Affinity-chromatography
克隆號(hào)：

32C2
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, WB

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
基因功能參考文獻(xiàn)：
1. an association between the GIPR rs2302382 polymorphism and type 2 diabetes mellitus in Egyptian patients. PMID: 28744963
2. Data suggest that GIPR (gastric inhibitory polypeptide receptor) is among the few GPCRs (G-protein-coupled receptors) which signal through G-proteins (GTP-binding protein Gs alpha subunit, here) both at plasma membrane and in endosomes; recombinant proteins expressed in HEK293 cells were used in these studies. PMID: 27641811
3. GIPR overexpression does not appear to affect acromegalic patients' clinical features PMID: 28179449
4. Study shows the internalization of GIPR involving clathrin-coated pits, AP-2 and dynamin and its subsequent intracellular trafficking. GIP stimulates a rapid robust internalization of the GIPR, the major part being directed to lysosomes. PMID: 26225752
5. The common variant rs10423928 in the GIPR gene is associated with increased risk of stroke in patients with type 2 diabetes. PMID: 26395740
6. Body mass index change for the A/T+A/A in GIPR genotypes was significantly higher than that for the T/T genotype. rs10423928 may predict weight gain in schizophrenia. PMID: 25321336
7. The potential future role of gastric inhibitory peptide (GIP) receptors as molecular targets in neuroendocrine neoplasms may be dependent on the tumor grade. PMID: 25591947
8. Results show that GIPR undergoes trafficking between the plasma membrane and intracellular compartments of both GIP-stimulated and unstimulated adipocytes. PMID: 25047836
9. GIPR is overexpressed in gastric and duodenal neuroendocrine tumors PMID: 24565507
10. GIPR expression was downregulated in subcutaneous adipose tissue from obese patients and correlated negatively with body mass index, waist circumference, systolic blood pressure, and glucose and triglyceride levels. PMID: 24512489
11. GIPR promoter was hypomethylated in type 2 diabetic patients as compared to controls. PMID: 24086540
12. This study demonstrates an association between a functional GIPR polymorphism Glu354Gln (rs1800437) and Bone mineral density and fracture risk. PMID: 24446656
13. Compared with the current treatment standard SSTR2, GIPR has only somewhat lesser absolute gene expression in tumor tissue but much lesser expression in normal tissue, making it a promising new target for neuroendocrine tumor imaging and therapy. PMID: 24238043
14. Structural and pharmacological characterization of novel potent and selective monoclonal antibody antagonists of glucose-dependent insulinotropic polypeptide receptor. PMID: 23689510
15. Functional expression of a GIP receptor mutant lacking N-glycosylation is rescued by co-expressed wild type GLP1 receptor, which suggests formation of a GIP-GLP1 receptor heteromer. PMID: 22412906
16. Our prospective, observational study indicates that the type 2 diabetes risk by dietary intake of carbohydrate and fat may be dependent on GIPR genotype. PMID: 22399504
17. Most of the somatostatin receptor-negative neuroendocrine tumors and GLP-1 receptor-negative malignant insulinomas are GIP receptor positive. PMID: 22112810
18. The T allele of GIPR rs2287019 is associated with greater improvement of glucose homeostasis in individuals who choose a low-fat, high-carbohydrate, and high-fiber diet. PMID: 22237064
19. a role of the adipocyte GIPr in nutrient-dependent regulation of body weight and lean mass, but it does not support a direct and independent role for the adipocyte or beta-cell GIPr in promoting adipogenesis. PMID: 22027838
20. Variations of the GIPR sequence are not associated with childhood obesity. PMID: 20516203
21. Variants at the GIPR locus associated with 2-h glucose level (rs10423928, beta (s.e.m.) = 0.09 (0.01) mmol/l per A allele, P = 2.0 x 10(-15)), were identified. PMID: 20081857
22. Proximal 5' flanking region is TATA-less and contains a GC-rich region involved in cellular expression. PMID: 12530665
23. differences in cellular response to gastric inhibitory polypeptide(GIP) mediated by endothelin-1 may be related to differences in activation of GIP receptor splice variants PMID: 12721154
24. Glucose-stimulated insulin secretion is maintained despite complete absence of both GIP-1 and GIP receptors. Role for incretin receptors as essential downstream targets for glucoregulatory actions of DPP-IV inhibitors. PMID: 15111503
25. Proximal promoter of GIP-R gene contains a GC-rich region capable of binding to Sp1 and SP3. PMID: 15666829
26. the promoter region of the GIP-R gene revealed six consensus sequences important in regulating the reporter gene activity and capable of binding to Sp1 and Sp3 transcription factors PMID: 16087722
27. GIPR adipose tissue gene expression was significantly lower in insulin resistant obese non-diabetic women PMID: 17395281
28. GIPR overexpression was observed in pediatric and adult adrenocortical tumors PMID: 18971217
29. Diabetic kidney lesions of GIPRdn transgenic mice: podocyte hypertrophy and thickening of the GBM precede glomerular hypertrophy and glomerulosclerosis. PMID: 19211686
30. Our data suggest a potential relevance of GIPR variants for obesity. PMID: 19254363
31. Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GLP-1R and GIP-R. PMID: 19386626
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亞細(xì)胞定位：

Cell membrane; Multi-pass membrane protein.
蛋白家族：

G-protein coupled receptor 2 family
數(shù)據(jù)庫(kù)鏈接：

HGNC: 4271

OMIM: 137241

KEGG: hsa:2696

STRING: 9606.ENSP00000467494

UniGene: Hs.251412

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