FRG1 Recombinant Monoclonal Antibody
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中文名稱：FRG1 Recombinant Monoclonal Antibody
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貨號(hào)：CSB-RA226988A0HU
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規(guī)格：￥1320
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圖片：
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Flow cytometric analysis of FRG1 expression in HeLa cells using FRG1 antibody. Green, isotype control; red, FRG1. -
Immunocytochemical staining of Hela cells with FRG1 antibody. Nuclei were stained blue with DAPI; FRG1 was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar: 20 μm. -
Western blotting analysis using FRG1 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with FRG1 antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：FRG1
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別名：FRG1; FSHD Region Gene 1; FRG1A; FSG1; FSHD Region Gene 1 Protein; Protein FRG1; Facioscapulohumeral Muscular Dystrophy Region Gene-1
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反應(yīng)種屬：Human
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免疫原：Recombinant Human FRG1 protein
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Non-conjugated
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克隆類型：Monoclonal
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抗體亞型：Rabbit IgG
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純化方式：Affinity-chromatography
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克隆號(hào)：7B11
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Rabbit IgG in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA, WB, FC, ICC
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推薦稀釋比：
Application Recommended Dilution WB 1:1000-1:5000 FC 1:200-1:2000 ICC 1:100-1:1000 -
Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：Binds to mRNA in a sequence-independent manner. May play a role in regulation of pre-mRNA splicing or in the assembly of rRNA into ribosomal subunits. May be involved in mRNA transport. May be involved in epigenetic regulation of muscle differentiation through regulation of activity of the histone-lysine N-methyltransferase KMT5B.
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基因功能參考文獻(xiàn)：
- Immunohistochemistry analysis showed reduced FRG1 levels in tumors which were supported by in silico analysis data. These findings suggest that reduction in FRG1 expression in gastric, colon and oral cavity tumor might have a role in tumor progression, by regulating cell migration and invasiveness. To elucidate a better understanding of molecular signaling involving FRG1 in angiogenesis regulation, further study is requir PMID: 28947680
- Penetrance of FSHD1 is low for largest alleles in the range of 9-10 RUs, and lower in women than men. PMID: 25603992
- Our results demonstrate that FRG1 is a direct DUX4 transcriptional target uncovering a novel regulatory circuit contributing to Facioscapulohumeral muscular dystrophy. PMID: 25326393
- Study showed that the variability in clinical severity of facioscapulohumeral muscular dystrophy in FSHD1 and FSHD2 individuals is dependent on individual differences in susceptibility to D4Z4 hypomethylation. PMID: 25256356
- This study suggests a novel role of FRG1 as epigenetic regulator of muscle differentiation and indicates that Suv4-20h1 has a gene-specific function in myogenesis. PMID: 23720823
- new insights into the gene deregulation characterizing both FSHD-1 and FSHD-2, in which miRNAs may play a role PMID: 21695143
- depressed myoblast proliferation may contribute to the pathology of mice overexpressing FRG1 and may play a part in facioscapulohumeral muscular dystrophy PMID: 21603621
- These data provide the first biochemical activities (actin binding and RNA binding) for human FRG1 and the characterization of the endogenous human FRG1, together indicating that FRG1 is involved in multiple aspects of RNA biogenesis. PMID: 21699900
- in muscle FRG1 is a developmentally regulated sarcomeric protein suggesting FRG1 may perform a muscle-specific function PMID: 20970242
- FRG1 transgenic mice develop a muscular dystrophy with features characteristic of the human disease; by contrast, FRG2 and ANT1 transgenic mice seem normal PMID: 16341202
- differently from normal myoblasts, the 4qA/B marker interacted directly with the promoters of the FRG1 and ANT1 genes in Facio-Scapulo-Humeral Dystrophy cells PMID: 18852887
- Data show that frg1 is expressed in and essential for the development of the tadpole musculature, and suggest that maintenance of normal FRG1 levels is critical for proper muscle development in frogs and humans. PMID: 19097195
- study compared chromatin structure & tridimensional interaction of the D4Z4 array and FRG1 gene promoter, and FRG1 expression, in control and FSHD cells PMID: 19607661
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相關(guān)疾病：Facioscapulohumeral muscular dystrophy 1 (FSHD1)
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亞細(xì)胞定位：Nucleus, Cajal body. Nucleus, nucleolus. Cytoplasm. Cytoplasm, myofibril, sarcomere, Z line.
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蛋白家族：FRG1 family
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組織特異性：Expressed in adult muscle, lymphocytes, fetal brain, muscle, and placenta. Also expressed in the smooth muscle of arteries and veins, the sweat glands and the epidermis.
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數(shù)據(jù)庫鏈接：
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