ELOVL5 Recombinant Monoclonal Antibody
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中文名稱：ELOVL5 Recombinant Monoclonal Antibody
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貨號：CSB-RA966922A0HU
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規(guī)格：￥1320
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圖片：
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Flow cytometric analysis of ELOVL5 expression in HepG2 cells using ELOVL5 antibody. Green, isotype control; red, ELOVL5. -
Immunocytochemical staining of HepG2 cells with ELOVL5 antibody. Nuclei were stained blue with DAPI; ELOVL5 was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar: 20 μm. -
Western blotting analysis using ELOVL5 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with ELOVL5 antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：ELOVL5
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別名：ELOVL5; ELOVL Fatty Acid Elongase 5; HELO1; DJ483K16.1; ELOVL Family Member 5, Elongation Of Long Chain Fatty Acids (FEN1/Elo2, SUR4/Elo3-Like, Yeast); Elongation Of Very Long Chain Fatty Acids Protein 5; Very Long Chain 3-Ketoacyl-CoA Synthase 5; Very Long Chain 3-Oxoacyl-CoA Synthase 5; 3-Keto Acyl-CoA Synthase ELOVL5; Spinocerebellar Ataxia 38; Fatty Acid Elongase 1; ELOVL FA Elongase 5; SCA38; Homolog Of Yeast Long Chain Polyunsaturated Fatty Acid Elongation Enzyme; EC 2.3.1.199; ELOVL2
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反應(yīng)種屬：Human
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免疫原：Recombinant Human ELOVL5 protein
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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克隆類型：Monoclonal
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抗體亞型：Rabbit IgG
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純化方式：Affinity-chromatography
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克隆號：7G10
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Rabbit IgG in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA, WB, FC, ICC
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推薦稀釋比：
Application Recommended Dilution WB 1:1000-1:5000 FC 1:200-1:2000 ICC 1:100-1:1000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情
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功能：Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate in the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. In conditions where the essential linoleic and alpha linoleic fatty acids are lacking it is also involved in the synthesis of Mead acid from oleic acid.
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基因功能參考文獻：
- Low ELOVL5 expression is associated with colorectal cancer. PMID: 28931069
- common variations associated with polyunsaturated fatty acid levels in breast milk PMID: 28245901
- SCA38 subtype is very rare in Mainland China; no disease-related gene mutations in ELOVL5. PMID: 26433464
- performed a detailed promoter/enhancer analysis of ELOVL5 gene, and identified two new SREBP binding sites, one in the 10 kb upstream region and one in the exon 1 PMID: 26321664
- In transfection experiments, subcellular localization of altered ELOVL5 showed a perinuclear distribution with a signal increase in the Golgi compartment, whereas the wild-type showed a widespread signal in the endoplasmic reticulum. PMID: 25065913
- Changes in the mRNA-expression levels of FADS1 and 2 directly affect blood DGLA levels and D6D activity. This study suggests that lower mRNA-expressions of FADS2 and ELOVL5 are associated with higher risk of atopic eczema in young children. PMID: 24167612
- a novel link between Elovl5-mediated synthesis of 18:1,n-7 and GNG through the control of the mTORC2-Akt-FoxO1 pathway PMID: 23099444
- minor allele copies at rs2294867 associated with an increase in total and LDL cholesterol...number of minor allele copies at rs761179 associated with increase in total cholesterol... However, associations not replicated in independent populations. PMID: 22293571
- Typical POAG associated with ELOVL5 gene polymorphism may have a late rather than an early onset. PMID: 21508110
- Not being breastfed resulted in a disadvantage in cognition (5 to 8 points) among children CC homozygote for rs2397142 (low ELOVL5 activity), but not among those carrying the G allele. PMID: 21383846
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相關(guān)疾病：Spinocerebellar ataxia 38 (SCA38)
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亞細胞定位：Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell projection, dendrite.
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蛋白家族：ELO family, ELOVL5 subfamily
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組織特異性：Ubiquitous. Highly expressed in the adrenal gland and testis. Weakly expressed in prostate, lung and brain. Expressed in the cerebellum.
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數(shù)據(jù)庫鏈接：
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