DPYSL3 Recombinant Monoclonal Antibody

說明書

中文名稱：

DPYSL3 Recombinant Monoclonal Antibody
貨號：

CSB-RA253654A0HU
規格：

￥1320
圖片：
Flow cytometric analysis of Dihydropyrimidinase like 3 expression in HT-1080 cells using Dihydropyrimidinase like 3 antibody. Green, isotype control; red, Dihydropyrimidinase like 3.

Immunocytochemical staining of HT-1080 cells with Dihydropyrimidinase like 3 antibody. Nuclei were stained blue with DAPI; Dihydropyrimidinase like 3 was stained magenta with Alexa Fluor? 647. Images were taken using leica stellaris 5. Protein abundance based on laser intensity and smart gain: Medium. Scale bar: 20 μm.

Western blotting analysis using Dihydropyrimidinase like 3 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with Dihydropyrimidinase like 3 antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
其他：

產品詳情
產品評價
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靶點詳情

產品詳情

Uniprot No.：

Q14195
基因名：

DPYSL3
別名：

DPYSL3; Dihydropyrimidinase Like 3; DRP-3; CRMP4; ULIP; Dihydropyrimidinase-Related Protein 3; Unc-33-Like Phosphoprotein 1; CRMP-4; ULIP-1; DRP3; Collapsin Response Mediator Protein 4 Long; Collapsin Response Mediator Protein 4; Testicular Secretory Protein Li 7; Dihydropyrimidinase-Like 3; LCRMP; ULIP1
反應種屬：

Human, Mouse, Rat
免疫原：

Recombinant Human DPYSL3 protein
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Monoclonal
抗體亞型：

Rabbit IgG
純化方式：

Affinity-chromatography
克隆號：

5H10
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Rabbit IgG in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

ELISA, WB, FC, ICC

推薦稀釋比：

Application	Recommended Dilution
WB	1:1000-1:5000
FC	1:200-1:2000
ICC	1:100-1:1000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Flow cytometry (FC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration.
基因功能參考文獻：
1. Data indicate that CRMP4a and CRMP4b isoforms have opposite effects on cell proliferation, migration, and invasion in gastric cancer. CRMP4a expression was reduced in gastric carcinoma tissues and cell lines and seems to act as a tumor suppressor in gastric carcinoma. CRMP4b expression was higher in tumor tissue and cell lines. PMID: 27475326
2. DPYSL3 expression levels inversely correlated with those of VEGF and FAK. Down-regulation of DPYSL3 expression in HCC tissues may serve as a predictive biomarker for HCC after curative resection. PMID: 25173447
3. Expression status of DPYSL3 in gastric cancer tissues may represent a promising biomarker for the malignant behavior of GC. PMID: 25096402
4. DPYSL3 as pancreatic ductal adenocarcinoma-associated molecule that regulates cell adhesion and migration by stabilization of focal adhesion complex PMID: 24339867
5. structures provide further insight into the effects of medically relevant mutations of the DPYSL-3 gene encoding CRMP-4 and the putative enzymatic activities of CRMPs PMID: 24914979
6. High collapsin response mediator protein 4 expression is associated with liver metastasis in pancreatic cancer. PMID: 22805864
7. Downregulation of MYCN by small interfering RNA (siRNA) increased DPYSL3 levels, while upregulation of MYCN in non-MYCN NB cells decreased DPYSL3 levels. PMID: 24011394
8. study found the association between the rs147541241 variant and amyotrophic lateral scerosis was limited to the French population PMID: 23568759
9. Ulip1 was downregulated and HIF1a was upregulated in hypoxic neuroblastoma cells. PMID: 20977846
10. CRMP4 is a key physiological substrate of GSK3 in regulating chromosomal alignment and mitotic progression through its effect on spindle microtubules PMID: 21179545
11. Data show that two genes, LTB4DH and DPYSL3, were confirmed to be candidate genes for the predictor of a good immune response. PMID: 20804502
12. new function of CRMP4 as a metastasis-suppressor in lymph node metastasis of prostate cancer PMID: 20543870
13. HUlip was expressed in late fetal and early postnatal brains in the neurons of the brain stem, basal ganglia/thalamus, and dentate gyrus of the hippocampus. HUlip expression was easily detected in tumor cells undergoing neuronal differentiation. [Ulip] PMID: 15933812
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亞細胞定位：

Cytoplasm. Cell projection, growth cone.
蛋白家族：

Metallo-dependent hydrolases superfamily, Hydantoinase/dihydropyrimidinase family
組織特異性：

Mainly expressed in heart and skeletal muscle. Also strongly expressed in fetal brain and spinal cord.
數據庫鏈接：

HGNC: 3015

OMIM: 601168

KEGG: hsa:1809

STRING: 9606.ENSP00000343690

UniGene: Hs.519659

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