CTPS1 Recombinant Monoclonal Antibody

說明書

中文名稱：

CTPS1重組抗體
貨號：

CSB-RA548305A0HU
規格：

￥1320
圖片：
IHC image of CSB-RA548305A0HU diluted at 1:100 and staining in paraffin-embedded human salivary gland tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品描述：

CTPS1 Recombinant Monoclonal Antibody（CSB-RA548305A0HU）是針對胞苷三磷酸合成酶1（CTPS1）開發的高特異性科研試劑，該靶點作為嘧啶核苷酸生物合成通路中的關鍵限速酶，通過催化UTP轉化為CTP參與DNA/RNA合成，在細胞增殖調控及腫瘤發生發展中具有重要作用。本抗體采用重組技術制備，經ELISA和免疫組化（IHC）雙重驗證，在石蠟包埋組織切片中展現優異的抗原識別能力，推薦使用濃度范圍為1:50至1:200時可獲得清晰的胞內定位信號，適用于檢測多種生物樣本中CTPS1蛋白的表達水平。憑借單克隆抗體特有的高批次一致性，該產品可為腫瘤生物學研究、細胞代謝機制探索以及增殖相關疾病模型的建立提供可靠工具，特別適用于癌癥發生機制、藥物靶點篩選和細胞周期調控等基礎研究領域。
Uniprot No.：

P17812
基因名：

CTPS1
別名：

CTP synthase 1 (EC 6.3.4.2) (CTP synthetase 1) (UTP--ammonia ligase 1), CTPS1, CTPS
反應種屬：

Human
免疫原：

A synthesized peptide derived from human CTPS1
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Monoclonal
抗體亞型：

Rabbit IgG
純化方式：

Affinity-chromatography
克隆號：

13B6
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

This enzyme is involved in the de novo synthesis of CTP, a precursor of DNA, RNA and phospholipids. Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as a source of nitrogen. This enzyme and its product, CTP, play a crucial role in the proliferation of activated lymphocytes and therefore in immunity.
基因功能參考文獻：
1. CTP synthase forms the cytoophidium in human hepatocellular carcinoma. PMID: 29097181
2. The filament structures elucidate allosteric mechanisms of assembly and regulation that rely on a conserved conformational equilibrium. The findings may provide a mechanism for increasing human CTP synthase activity in response to metabolic state and challenge the assumption that metabolic filaments are generally storage forms of inactive enzymes. PMID: 28459447
3. Rods and rings (RR) are protein assemblies composed of CTPS1 and IMPDH2. Glutamine deprivation initiates reversible assembly of mammalian rods and rings. PMID: 24477477
4. results highlight a key and specific role of CTPS1 in the immune system by its capacity to sustain the proliferation of activated lymphocytes during the immune response PMID: 24870241
5. analysis of the kinetic properties of hCTPS1 and hCTPS2, and determination that Ser(68) is a major site of CTPS2 regulation by phosphorylation PMID: 20739275
6. CTP synthetase is phosphorylated by protein kinase A PMID: 16179339
7. Data indicate that protein kinase C phosphorylation at Ser(462) stimulates human CTP synthetase 1 activity, whereas phosphorylation at Thr(455) inhibits activity. PMID: 17463002
8. analysis of phosphorylation and regulation of human CTPS1 in human cells shows that GSK3 is a novel regulator of CTPS activity PMID: 17681942
9. studies provide novel information on the potential interacting proteins that may regulate CTPS1 function or intracellular localization PMID: 18600551
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相關疾病：

Immunodeficiency 24 (IMD24)
亞細胞定位：

Cytoplasm, cytosol.
蛋白家族：

CTP synthase family
組織特異性：

Widely expressed.
數據庫鏈接：

HGNC: 2519

OMIM: 123860

KEGG: hsa:1503

STRING: 9606.ENSP00000361699

UniGene: Hs.473087

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