CRCP Recombinant Monoclonal Antibody

說明書

中文名稱：

CRCP Recombinant Monoclonal Antibody
貨號：

CSB-RA829023A0HU
規(guī)格：

￥1320
圖片：
Flow cytometric analysis of CGRP receptor component expression in HepG2 cells using CGRP receptor component antibody. Green, isotype control; red, CGRP receptor component.

Immunocytochemical staining of HepG2 cells with CGRP receptor component antibody. Nuclei were stained blue with DAPI; CGRP receptor component was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: High. Scale bar: 20 μm.

Western blotting analysis using CGRP receptor component antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with CGRP receptor component antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

Uniprot No.：

O75575
基因名：

CRCP
別名：

CRCP; CGRP Receptor Component; CGRP-RCP; Calcitonin Gene-Related Peptide-Receptor Component Protein; POLR3I; RCP9; RCP; C17; DNA-Directed RNA Polymerase III Subunit RPC9; CGRP-Receptor Component Protein; RNA Polymerase III Subunit C9; CGRPRCP; POLR3J; HsC17; RPC9
反應(yīng)種屬：

Human, Mouse
免疫原：

Recombinant Human CRCP protein
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

Non-conjugated
克隆類型：

Monoclonal
抗體亞型：

Rabbit IgG
純化方式：

Affinity-chromatography
克隆號：

16A8
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Rabbit IgG in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, WB, FC, ICC

推薦稀釋比：

Application	Recommended Dilution
WB	1:1000-1:5000
FC	1:200-1:2000
ICC	1:100-1:1000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Flow cytometry (FC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點(diǎn)詳情

功能：

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF- Kappa-B through the RIG-I pathway.; Accessory protein for the calcitonin gene-related peptide (CGRP) receptor. It modulates CGRP responsiveness in a variety of tissues.
基因功能參考文獻(xiàn)：
1. data reinforce and clarify our understanding of CGRP receptor localization, and provide evidence that antagonist antibodies bind to target sites in the trigeminovascular system of primates that are involved in the pathology of migraine PMID: 27155150
2. CGRP family of receptors displays both ligand- and RAMP-dependent signaling bias among the Galphas, Galphai, and Galphaq/11 pathways. PMID: 27566546
3. In this review, the influence of the CGRP family peptides in reproduction and pregnancy is explored and discussed. PMID: 25015815
4. This study demonstrates the detailed expression of CGRP and its receptor components within spinal trigeminal nucleus in the brainstem and in the spinal cord at C1-level PMID: 22074408
5. The extracellular protein domains corresponding to residues 23-133 of calcitonin receptor-like receptor and residues 26-117 of receptor activity-modifying protein 1 (RAMP1) are shown to be sufficient for formation of a stable, folded monodisperse complex. PMID: 20099900
6. Expression of CGRP-RCP was detected in CD34+ cells and also in some mature granulocyte samples, providing evidence that CGRP-RCP may be regulated independently of RAMP1 and CRLR in hematopoietic cells. PMID: 11937264
7. human CGRP-RCP is the genuine orthologue of C17. CGRP-RCP was found to functionally replace C17 in Deltarpc17 yeast cells; CGRP-RCP was identified in a purified human Pol III preparation. PMID: 12482973
8. inhibition of ACE seems to augment CGRP catabolism. PMID: 16406141
9. Increased mRNA expression CGRP-RCP in gravid myometrium supports the possibility of involvement of CGRP in the control of myometrial contractility. PMID: 17853344
10. A peptide mimetic demonstrates that 12 residues of family B member CGRP receptor proximal C-terminus are required for this receptor's expression and localization at the cell membrane. PMID: 18636754
11. analysis of the effects of antagonists to the CGRP receptor PMID: 19053766
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亞細(xì)胞定位：

Nucleus. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
蛋白家族：

Eukaryotic RPC9 RNA polymerase subunit family
組織特異性：

Ubiquitous. Most prevalent in testis.
數(shù)據(jù)庫鏈接：

HGNC: 17888

OMIM: 606121

KEGG: hsa:27297

STRING: 9606.ENSP00000378736

UniGene: Hs.300684

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