ADK Recombinant Monoclonal Antibody

說明書

中文名稱：

ADK Recombinant Monoclonal Antibody
貨號：

CSB-RA976312A0HU
規格：

￥1320
圖片：
Immunocytochemical staining of HAP-1 cells with ADK antibody. Nuclei were stained blue with DAPI; ADK was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar, 20 μm.

Western blotting analysis using ADK antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with ADK antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
其他：

產品詳情
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相關產品
靶點詳情

產品詳情

Uniprot No.：

P55263
基因名：

ADK
別名：

ADK; Adenosine Kinase; AK; Adenosine 5'-Phosphotransferase; EC 2.7.1.20; Testicular Tissue Protein Li 14; EC 2.7.1
反應種屬：

Human
免疫原：

Recombinant Human ADK protein
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Monoclonal
抗體亞型：

Rabbit IgG
純化方式：

Affinity-chromatography
克隆號：

16G7
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Rabbit IgG in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

ELISA, WB, ICC

推薦稀釋比：

Application	Recommended Dilution
WB	1:1000-1:5000
ICC	1:100-1:1000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides.
基因功能參考文獻：
1. The results of this study showed that over-expression of the major adenosine removing enzyme ADK in reactive astrocytes and subpopulation of remaining neurons in Rasmussen Encephalitis patients plays an important role in the epileptogensis of Rasmussen Encephalitis. PMID: 28789481
2. rs11001109 rare allele homozygosity is associated with increased risk of post-traumatic epilepsy development after brain injury. PMID: 26040919
3. The results of this study suggest that upregulation of ADK is a common pathologic component of FCDIIB. PMID: 25575137
4. These results suggest that upregulation of ADK is a common pathologic hallmark of Rasmussen encephalitis and that ADK might be a target in the treatment of epilepsy associated with Rasmussen encephalitis. PMID: 24128682
5. Data show that we a significantly higher expression of ADK in the peritumoral infiltrated tissue of patients with epilepsy than in patients without epilepsy. PMID: 22092111
6. The results of this study suggested that dysregulation of ADK in astrocytes is a common pathologic hallmark of temporal lobe epilepsy. PMID: 21635241
7. The cytoplasmic isoform of adenosine kinase is sufficient to alter sleep physiology. ADK might orchestrate neurotransmitter pathways involved in the generation of electroencephlogram oscillations and regulation of sleep. PMID: 20881134
8. The catalytic properties, gene expression and protein levels of certain proteins involved in mitochondrial ATP synthesis, such as F1F0-ATPase, ANT and AK, in human skin fibroblasts with trisomic karyotype, compared them with euploid fibroblasts. PMID: 20698827
9. Equilibrative nucleoside transporters (hENT1, hENT2) together with adenosine kinase and 5'-nucleotidase play a crucial role in the regulation of CFTR through an adenosine-dependent pathway in human airway epithelia. PMID: 12820662
10. role for HIF-1alpha in transcriptional repression of AK in hypoxia PMID: 18309031
11. adenosine kinase gene expression was significantly higher in cancer than in normal-appearing tissue, in line with our previous measurements of adenosine kinase enzyme activities in colorectal tumor samples PMID: 18600536
12. both deoxycytidine kinase and adenosine kinase are involved in this model of ADA deficiency PMID: 18600545
13. This study reports for the first time subcellular localization of the enzyme AdK in mammalian cells. PMID: 19635462
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相關疾病：

Hypermethioninemia due to adenosine kinase deficiency (HMAKD)
亞細胞定位：

[Isoform 1]: Nucleus.; [Isoform 2]: Cytoplasm.
蛋白家族：

Carbohydrate kinase PfkB family
組織特異性：

Widely expressed. Highest level in placenta, liver, muscle and kidney.
數據庫鏈接：

HGNC: 257

OMIM: 102750

KEGG: hsa:132

STRING: 9606.ENSP00000286621

UniGene: Hs.656586

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