pstS1 Antibody, HRP conjugated

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說明書

中文名稱：

pstS1兔多克隆抗體, HRP偶聯(lián)
貨號：

CSB-PA14919B0Rb
規(guī)格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Mycobacterium tuberculosis pstS1 Polyclonal antibody
Uniprot No.：

P9WGU1
基因名：

pstS1
別名：

pstS1 antibody; phoS1 antibody; Rv0934 antibody; MTCY08D9.05c antibody; Phosphate-binding protein PstS 1 antibody; PBP 1 antibody; PhoS1 antibody; PstS-1 antibody; 38-kDa glycolipoprotein antibody; 38-kDa lipoprotein antibody; P38 antibody; Antigen Ag78 antibody; Protein antigen B antibody; Pab antibody
宿主：

Rabbit
反應種屬：

Mycobacterium tuberculosis
免疫原：

Recombinant Mycobacterium tuberculosis Phosphate-binding protein PstS 1 protein (24-373AA)
免疫原種屬：

Mycobacterium tuberculosis
標記方式：

HRP
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Functions in inorganic phosphate uptake, although probably not the main uptake protein under phosphate starvation. Binds phosphate; probably able to bind both H(2)PO(4)(-) and HPO(4)(2-). Part of the ABC transporter complex PstSACB involved in phosphate import.; A host TLR2 agonist (toll-like receptor), shown experimentally for human and mouse. Requires both host TLR1 and TLR2 as coreceptors to elicit host response in mouse (TLR6 may also play a role) neither CD14 or CD36 function as accessory receptors. Protein purified from culture filtrate induces host (human) monocytes to produce TNF-alpha, IL-6 and IL-12 p40 (IL12B) via ERK1/2 (MAPK3 and MAPK1) and p38 MAPK pathways; MEK inhibitors U0126 and PD98059 and p38 inhibitor SB203580 block most cytokine production. Host ERK1/2 and p38 MAPK activation is mediated mainly by TLR2, but also partially by TLR4, and unlike the case for lipoprotein LpqH the protein moiety of PstS1 seems to be the antigenic agent. Greater activation of ERK1/2 and p38 MAPK is seen in patients with active pulmonary tuberculosis than in tuberculin-negative patients. Induces apoptosis when incubated with human monocyte-derived macrophages via TLR2. Protein purified from culture filtrate acts via TLR2 and TLR4 to induce host macrophage (shown for mouse) endoplasmic reticulum stress-mediated apoptosis via MAPK (at least JNK), C-C motif chemokine 2 (MCP-1, Ccl2) and ZC3H12 endoribonucleases (MCPIP, Zc3h12). Functions as an adhesin, binds to human and mouse macrophages via mannose residues, binds to the mouse macrophage mannose receptor (possibly Mrc1) and mediates bacterial phagocytosis.
基因功能參考文獻：
1. The interaction of PstS-1 coated beads with the mannose receptor was confirmed by confocal colocalization studies that showed high Pearson and Manders's colocalization coefficients. PMID: 25359607
2. pstS1 polymorphisms of Mycobacterium tuberculosis strains may reflect ongoing immune evasion. PMID: 23849889
3. Data indicate that the modulation of Natural killer (NK) cells by PstS-1 is mediated via monocytes. PMID: 23036052
亞細胞定位：

Cell membrane; Lipid-anchor. Cell surface. Secreted, cell wall. Secreted.
蛋白家族：

PstS family
數(shù)據(jù)庫鏈接：

KEGG: mtu:Rv0934

STRING: 83332.Rv0934

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