Recombinant Bovine Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PPP2CA)
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中文名稱：牛PPP2CA重組蛋白
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貨號：018559BO
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規格：
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其他：
產品詳情
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Uniprot No.：
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基因名：
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別名：PPP2CA; Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; PP2A-alpha; EC 3.1.3.16
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免疫原種屬：Bos taurus (Bovine)
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
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應用說明：Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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儲存條件：The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. -
貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
靶點詳情
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功能：PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Can dephosphorylate p53/TP53. Activates RAF1 by dephosphorylating it at 'Ser-259'. Mediates dephosphorylation of WEE1, preventing its ubiquitin-mediated proteolysis, increasing WEE1 protein levels, and promoting the G2/M checkpoint. Mediates dephosphorylation of MYC; promoting its ubiquitin-mediated proteolysis: interaction with AMBRA1 enhances interaction between PPP2CA and MYC. Mediates dephosphorylation of FOXO3; promoting its stabilization: interaction with AMBRA1 enhances interaction between PPP2CA and FOXO3.
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基因功能參考文獻：
- changes in PP2A activity due to methylation and tyrosine phosphorylation occur in sperm; these changes may play an important role in the regulation of sperm function PMID: 26569399
- The findings demonstrate an endothelial VEGF resistance mechanism conferred by palmitic acid, which comprises ceramide-induced, PP2A-mediated dephosphorylation of critical activation sites on enzymes central to vascular homeostasis and angiogenesis. PMID: 24606881
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亞細胞定位：Cytoplasm. Nucleus. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle pole.
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蛋白家族：PPP phosphatase family, PP-1 subfamily
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數據庫鏈接：
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