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中文名稱：cagA兔多克隆抗體
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貨號(hào)：CSB-PA14367A0Rb
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規(guī)格：￥440
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱：Rabbit anti-Helicobacter pylori cagA Polyclonal antibody
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Uniprot No.：
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基因名：cagA
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別名：cagA antibody; cag26 antibody; cai antibody; HP_0547Cytotoxicity-associated immunodominant antigen antibody; 120 kDa protein antibody; CAG pathogenicity island protein 26 antibody
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宿主：Rabbit
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反應(yīng)種屬：Helicobacter pylori
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免疫原：Recombinant Helicobacter pylori Cytotoxicity-associated immunodominant antigen protein (1-294AA)
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免疫原種屬：Helicobacter pylori
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標(biāo)記方式：Non-conjugated
本頁面中的產(chǎn)品，cagA Antibody (CSB-PA14367A0Rb)，的標(biāo)記方式是Non-conjugated。對于cagA Antibody，我們還提供其他標(biāo)記。見下表：
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA
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Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：May be necessary for the transcription, folding, export, or function of the cytotoxin.
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基因功能參考文獻(xiàn)：
- The authors conclude that CagQ is a membrane protein in a type IV secretion system and is crucial for maintaining CagA expression and CagA-induced apoptotic effects. PMID: 29306012
- The vacuolating cytotoxin autotransporter (vacA) c1 genotype, but not cytotoxicity-associated immunodominant antigen (cagA) status, might be the first important bacterial biomarker for predicting the cardia adenocarcinoma risk. PMID: 29036792
- In this study, through quantitative analysis of the complex formation between CagA and PAR1b, the authors found that several CagA species have acquired elevated PAR1b-binding activity via duplication of the CagA multimerization motifs, while others have lost their PAR1b-binding activity. PMID: 27445265
- Helicobacter pylori expressing cagA and vacA genes is prevalent in dyspeptic Ghanaian patients. PMID: 28655347
- H. pylori infection significantly inhibits the cleavage of TRAF1 via a CagA-dependent mechanism, which would increase the relative amounts of full-length TRAF1 and exert an antiapoptotic effect on H. pylori-infected cells. PMID: 28082808
- Data indicate that treatment of gastric epithelial cells with simvastatin reduced the level of cellular cholesterol and led to attenuation of translocation and phosphorylation of cytotoxin-associated gene A (CagA). PMID: 26730715
- Studies suggest that cytotoxin-associated gene A (CagA)-negative non-virulent strains of Helicobacter pylori may be a potential risk factor of pancreatic cancer. PMID: 26390415
- CagT plays an important role in the translocation of CagA into host epithelial cells. PMID: 23075784
- CagA upregulated CIP2A expression and this upregulation effect was dependent on Src and Ras/mitogen-activated protein kinase kinase/extracellular signal-regulated kinase pathways. PMID: 19959630
- In a stomach adenocarcinoma cell line, an increase in this protein correlated with the amount of the phosphorylated protein. PMID: 16278423
- These data demonstrate that VacA can downregulate CagA's effects on epithelial cells, a novel molecular mechanism showing how H. pylori can avoid excessive cellular damage. PMID: 19046339
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數(shù)據(jù)庫鏈接：
KEGG: heo:C694_02825
STRING: 85962.HP0547
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