ZWINT Antibody
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中文名稱：ZWINT兔多克隆抗體
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貨號：CSB-PA527261LA01HU
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規(guī)格：￥440
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圖片：
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IHC image of CSB-PA527261LA01HU diluted at 1:100 and staining in paraffin-embedded human ovarian cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱：Rabbit anti-Homo sapiens (Human) ZWINT Polyclonal antibody
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Uniprot No.：
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基因名：ZWINT
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別名：ZW10 interactor (ZW10-interacting protein 1) (Zwint-1), ZWINT
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宿主：Rabbit
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反應(yīng)種屬：Human
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免疫原：Recombinant Human ZW10 interactor protein (1-277aa)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
本頁面中的產(chǎn)品，ZWINT Antibody (CSB-PA527261LA01HU)，的標記方式是Non-conjugated。對于ZWINT Antibody，我們還提供其他標記。見下表：
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA, IHC
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推薦稀釋比：
Application Recommended Dilution IHC 1:100-1:500 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情
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功能：Part of the MIS12 complex, which is required for kinetochore formation and spindle checkpoint activity. Required to target ZW10 to the kinetochore at prometaphase.
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基因功能參考文獻：
- ZW10 interactor was frequently decreased in hepatocellular carcinoma. PMID: 30198401
- Our results provide the first evidence that Zwint-1 is required to correct erroneous kinetochore-microtubule attachment and regulate spindle checkpoint function during meiosis. PMID: 26486467
- the E3 ubiquitin ligase terf causes protein degradation of ZWINT and negatively regulates cell proliferation PMID: 22023800
- These studies identify zwint-1 as a novel AurB substrate required for kinetochore assembly and for proper spindle assembly checkpoint silencing at metaphase PMID: 21775627
- hZwint-1 bridges the inner and outer kinetochore: identification of the kinetochore localization domain and the hZw10-interaction domain PMID: 21345172
- show that ZW10 interacting protein-1(Zwint-1) is required and is sufficient for kinetochore localization of Zeste White 10 (ZW10) in HeLa cells PMID: 15485811
- Stable hZW10 kinetochore residency at prometaphase kinetochores is dependent on its interaction with hZwint-1, and is essential for mitotic checkpoint arrest. PMID: 18268100
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亞細胞定位：Nucleus. Chromosome, centromere, kinetochore. Note=Localizes to kinetochores from late prophase to anaphase.
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數(shù)據(jù)庫鏈接：
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