ZP4 Antibody, Biotin conjugated
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中文名稱：ZP4兔多克隆抗體, Biotin偶聯
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貨號：CSB-PA621518LD01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) ZP4 Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：Processed zona pellucida sperm-binding protein 4 antibody; ZBP antibody; Zona pellucida B protein antibody; Zona pellucida glycoprotein 4 antibody; Zona pellucida protein B antibody; Zona pellucida sperm binding protein 4 antibody; Zp-4 antibody; ZP1 antibody; ZP4 antibody; ZP4_HUMAN antibody; ZPB antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Zona pellucida sperm-binding protein 4 protein (368-457AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Biotin
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP4 may act as a sperm receptor.
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基因功能參考文獻：
- ZO4 is highly expressed in ovarian tissue in PCOS patients with regular cycle and without hyperandrogenism; in some patients with PCOS and infertility, ZP4 mutation can be found. PMID: 25740067
- Human ZP4 is not sufficient to support human sperm binding to the zona pellucida in transgenic mice; other zona proteins may be needed for human gamete recognition. PMID: 21173071
- ZPB induces acrosomal exocytosis through a Gi independent pathway. PMID: 15805145
- Binding sites for recombinant zona pellucida B (ZPB) glycoprotein are located both at the N- and C-terminus of proacrosin PMID: 15950651
- Exposure of sperm to ZP proteins promoted acrosomal exocytosis and changed motility patterns. PMID: 16407501
- induces acrosome reactions which are protein kinase-C, protein tyrosine kinase, T-type Ca2+ channels, and extracellular Ca2+ dependent PMID: 18667750
- a significant decrease in acrosomal exocytosis mediated by both recombinant human ZP3 (p<0.005) and ZP4 (p<0.005) was observed in presence of the immune sera PMID: 19004505
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亞細胞定位：[Processed zona pellucida sperm-binding protein 4]: Zona pellucida.; Cell membrane; Single-pass type I membrane protein.
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蛋白家族：ZP domain family, ZPB subfamily
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組織特異性：Expressed in oocytes.
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數據庫鏈接：
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