ZNF384 Antibody, FITC conjugated
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中文名稱：ZNF384兔多克隆抗體, FITC偶聯
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貨號：CSB-PA03455C0Rb
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) ZNF384 Polyclonal antibody
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Uniprot No.：
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基因名：ZNF384
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別名：CAG repeat protein 1 antibody; CAGH1A antibody; CAS interacting zinc finger protein antibody; CAS-interacting zinc finger protein antibody; CIZ antibody; ERDA2 antibody; GH1A antibody; NMP4 antibody; NP antibody; Nuclear matrix protein 4 antibody; Nuclear matrix transcription factor 4 antibody; TNRC1 antibody; Trinucleotide repeat containing gene 1 protei antibody; Trinucleotide repeat-containing gene 1 protein antibody; Zinc finger protein 384 antibody; ZN384_HUMAN antibody; Znf384 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Zinc finger protein 384 protein (1-245AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：FITC
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產品提供形式：Liquid
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
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靶點詳情
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功能：Transcription factor that binds the consensus DNA sequence [GC]AAAAA. Seems to bind and regulate the promoters of MMP1, MMP3, MMP7 and COL1A1.
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基因功能參考文獻：
- Ectopic expression of EP300-ZNF384 and CREBBP-ZNF384 fusion altered differentiation of mouse hematopoietic stem and progenitor cells and also potentiated oncogenic transformation in vitro.our results indicate that gene fusion is a common class of genomic abnormalities in childhood ALL and that recurrent translocations involving EP300 and CREBBP may cause epigenetic deregulation with potential for therapeutic targeting. PMID: 27903646
- EP300-ZNF384 mediates GATA3 gene expression and may be involved in the acquisition of the HSC gene expression signature and characteristic immunophenotype in B-cell precursor acute lymphoblastic leukemia cells. PMID: 28378055
- Our observations indicate that ZNF384-related fusion genes consist of a distinct subgroup of B-cell precursor acute lymphoblastic leukemia with a characteristic immunophenotype, while the clinical features depend on the functional properties of individual fusion partners. PMID: 27634205
- the frequency of ZNF384 gene rearrangement in pediatric precursor B cell ALL is approximately 3%. PMID: 27392123
- nuclear matrix protein 4 overexpression increased Aquaporin 5 mRNA expression by 2.5-fold in HEK293 cells PMID: 27058007
- Rare translocation t(12;17)(p13;q12), This translocation has been reported in 25 cases and its putative molecular consequence, the formation of a TAF15-ZNF384 fusion gene, in only six cases. PMID: 21504714
- expression in pelvic lymph nodes and primary tumors in early stage cervical carcinomas PMID: 11956602
- The transcription factor gene CIZ/NMP4 is recurrently involved in acute leukemia through fusion with either EWSR1 or TAF15. PMID: 12359745
- The CIZ protein(also known as ZNF384)was involved and rearrangemented in acute leukemia. PMID: 15990865
- These results suggest that caspase-mediated degradation may represent a novel regulatory mechanism that controls TAF15 and TAF15-CIZ/NMP4 activities. PMID: 19426707
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亞細胞定位：Nucleus.
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蛋白家族：Krueppel C2H2-type zinc-finger protein family
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數據庫鏈接：
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