ZNF366 Antibody

中文名稱：

ZNF366兔多克隆抗體
貨號：

CSB-PA026702LA01HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA026702LA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA026702LA01HU at dilution of 1:100

Immunofluorescent analysis of A549 cells using CSB-PA026702LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
其他：

產品詳情
產品評價
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) ZNF366 Polyclonal antibody
Uniprot No.：

Q8N895
基因名：

ZNF366
別名：

ZNF366 antibody; Zinc finger protein 366 antibody; Dendritic cell-specific transcript protein antibody; DC-SCRIPT antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Zinc finger protein 366 protein (455-650AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，ZNF366 Antibody (CSB-PA026702LA01HU)，的標記方式是Non-conjugated。對于ZNF366 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA026702LB01HU	ZNF366 Antibody, HRP conjugated	ELISA
FITC	CSB-PA026702LC01HU	ZNF366 Antibody, FITC conjugated
Biotin	CSB-PA026702LD01HU	ZNF366 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Has transcriptional repression activity. Acts as corepressor of ESR1; the function seems to involve CTBP1 and histone deacetylases.
基因功能參考文獻：
1. These data demonstrate that besides nuclear receptor regulation, DC-SCRIPT also modulates activation of NF-kappaBp65 after TLR activation in human DCs. PMID: 26170389
2. these data show that DC-SCRIPT acts as a novel regulator of CDKN2B and induces cell cycle arrest in ESR1-positive breast cancer cells. PMID: 25663546
3. DC-SCRIPT serves an important role in regulating GR function in DCs, corepressing GR-dependent upregulation of the tolerance-inducing transcription factor GILZ. PMID: 23440419
4. DC-SCRIPT is a key regulator of androgen receptor and vitamin d receptor that play an opposite role in prostate cancer etiology and loss of DC-SCRIPT may be involved in the onset of prostate cancer. PMID: 22473304
5. DC-SCRIPT has a primary role in the regulation of interleukin (IL)-10 production by monocytes. PMID: 22615205
6. study provides a higher level of evidence that DC-SCRIPT is indeed an independent, pure prognostic, factor for primary breast cancer and shows that DC-SCRIPT mRNA expression is most informative for either ESR1-positive and/or ESR2-low pT1 tumors PMID: 21122099
7. DC-SCRIPT can act as a tumor suppressor in breast cancer development.[review] PMID: 20478364
8. DC-SCRIPT consists of a proline-rich region, 11 C2H2-type zinc fingers, and an acidic region. Localization studies reveal that DC-SCRIPT resides in the nucleus and that nuclear localization is critically dependent on the zinc fingers. (DC-SCRIPT) PMID: 16393996
9. Results indicate that ZNF366 may play an important role in regulating the expression of genes in response to estrogen. PMID: 17085477
10. Identification of ZNF366 and PTPRD as novel determinants of plasma homocysteine in a family-based genome-wide association study PMID: 19525478
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亞細胞定位：

Nucleus.
組織特異性：

Expressed in immature and mature dendritic cells (DCs). Not detected in other blood cell types.
數據庫鏈接：

HGNC: 18316

OMIM: 610159

KEGG: hsa:167465

STRING: 9606.ENSP00000313158

UniGene: Hs.224794

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