ZNF268 Antibody, Biotin conjugated
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中文名稱：ZNF268兔多克隆抗體, Biotin偶聯
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貨號：CSB-PA026625LD01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) ZNF268 Polyclonal antibody
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Uniprot No.：
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基因名：ZNF268
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別名：ZNF268Zinc finger protein 268 antibody; Zinc finger protein HZF3 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Zinc finger protein 268 protein (416-603AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Biotin
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Acts as a transcriptional repressor. Inhibits erythroid differentiation and tumor cell proliferation. Plays a role during ovarian cancer development and progression.; Contributes to cervical carcinogenesis in part through the TNF-alpha-induced NF-kappa-B signaling pathway by interacting with the I-kappa-B-kinase (IKK) core complex.
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基因功能參考文獻：
- The nuclear localization activity of KRAB domain is a conserved feature of ZNF268. PMID: 23665872
- These results reveal a novel role of ZNF268b2 that contributes to cervical carcinogenesis in part through enhancing NF-kappaB signaling. PMID: 23091055
- ZNF268 is a crucial downstream target and effector of GATA-1 PMID: 22235304
- This protein has a conserved KRAB domain which localizes to the nucleus and has transcriptional repressor activity. PMID: 12822888
- ZNF268 plays a role in early human liver development most likely by functioning through a cytoplasmic mechanism PMID: 15547661
- 4 alternative transcripts of ZNF268 were detected in the human blood cells. PMID: 16735226
- ZNF268 gene promoter is atypical and requires an intragenic element located within the first exon that mediates the effect of CREB for its activity PMID: 16787922
- ZNF268 gene may function as a transcriptional activator in the growth and differentiation of cells in development and/or pathogenesis. PMID: 16865230
- HTLV-1 oncoprotein tax represses ZNF268 expression through the cAMP-responsive element-binding PMID: 18375384
- results indicate that a spliced form of ZNF268 lacking the KRAB domain is located in the cytosol, where it seems to play a role in TNF-alpha-induced NF-kappaB activation by interacting with the IKK complex. PMID: 18677094
- Results demonstrate that the mammalian gene ZNF268 is regulated by hUpf1 via its promoter. PMID: 18774934
- aberrant alternative splicing of ZNF268 is a potential prognostic factor of and may contribute to human hematological malignancies. PMID: 18949428
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亞細胞定位：[Isoform 1]: Nucleus.; [Isoform 2]: Nucleus. Cytoplasm.
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蛋白家族：Krueppel C2H2-type zinc-finger protein family
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組織特異性：Overexpressed in ovarian cancer tissues compared to normal ovarian tissues. Isoform 1 and isoform 2 are expressed in squamous epithelium tissues. Isoform 2 is overexpressed in squamous cervical cancer (at protein level). Expressed in blood cells. Isoform
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數據庫鏈接：
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